ARNTL (aryl hydrocarbon receptor nuclear translocator like)

2009-09-01  

Identity

HGNC
LOCATION
11p15.3
LOCUSID
ALIAS
BMAL1,BMAL1c,JAP3,MOP3,PASD3,TIC,bHLHe5
FUSION GENES

Other Information

Locus ID:

NCBI: 406
MIM: 602550
HGNC: 701
Ensembl: ENSG00000133794

Variants:

dbSNP: 406
ClinVar: 406
TCGA: ENSG00000133794
COSMIC: ARNTL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133794ENST00000389707O00327
ENSG00000133794ENST00000389707A0A140VKD3
ENSG00000133794ENST00000401424O00327
ENSG00000133794ENST00000403290O00327
ENSG00000133794ENST00000403482O00327
ENSG00000133794ENST00000403510O00327
ENSG00000133794ENST00000482049E9PI92
ENSG00000133794ENST00000524392H0YER9
ENSG00000133794ENST00000527998E9PKG7
ENSG00000133794ENST00000529050E9PSD2
ENSG00000133794ENST00000529388E9PKF0
ENSG00000133794ENST00000529825E9PRB1
ENSG00000133794ENST00000530357E9PPV4
ENSG00000133794ENST00000531665E9PNI4
ENSG00000133794ENST00000533520E9PL54
ENSG00000133794ENST00000534544E9PKN1

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
252033212014A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer.147
164744062006Feedback repression is required for mammalian circadian clock function.112
177284042007Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.107
177284042007Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.107
128970572003BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.94
118750632002The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.91
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
165287482006Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.88
219664652011Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation.87
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85

Citation

Dessen P

ARNTL (aryl hydrocarbon receptor nuclear translocator like)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51125/arntl-(aryl-hydrocarbon-receptor-nuclear-translocator-like)