DHRS2 (dehydrogenase/reductase 2)

2009-09-01  

Identity

HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
HEP27,SDR25C1
FUSION GENES

Other Information

Locus ID:

NCBI: 10202
MIM: 615194
HGNC: 18349
Ensembl: ENSG00000100867

Variants:

dbSNP: 10202
ClinVar: 10202
TCGA: ENSG00000100867
COSMIC: DHRS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100867ENST00000250383Q13268
ENSG00000100867ENST00000344777Q13268
ENSG00000100867ENST00000432832C9JZP6
ENSG00000100867ENST00000553600H0YJG9
ENSG00000100867ENST00000557535H0YJP4
ENSG00000100867ENST00000611765Q13268

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205477512010Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.26
209490952010Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer.19
194439062009Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress.17
166854662006Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.10
75561961995A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family.9
230367052012Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.9
230367052012Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes.9
294367492018HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5-FU resistance by a p53-dependent pathway.9
119970862002A human short-chain dehydrogenase/reductase gene: structure, chromosomal localization, tissue expression and subcellular localization of its product.7
291063932018DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma.6

Citation

Dessen P

DHRS2 (dehydrogenase/reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51136/dhrs2-(dehydrogenase-reductase-2)