TBC1D3 (TBC1 domain family member 3)

2009-10-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
PRC17,TBC1D3A,TBC1D3C,TBC1D3D,TBC1D3F,TBC1D3L
FUSION GENES

Other Information

Locus ID:

NCBI: 729873
MIM: 607741
HGNC: 19031
Ensembl: ENSG00000274611

Variants:

dbSNP: 729873
ClinVar: 729873
TCGA: ENSG00000274611
COSMIC: TBC1D3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000274611ENST00000620215Q8IZP1

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
TBC/RABGAPsREACTOMER-HSA-8854214

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183192452008The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking.24
168636882006TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.23
223480582012TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity.22
230295302012Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase.8
288447142017Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.8
284227412017Calmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells.1
235786632013Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation.0
247141052014Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling.0
275048052016The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.0

Citation

Dessen P

TBC1D3 (TBC1 domain family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51139/tbc1d3-(tbc1-domain-family-member-3)