TBC1D3 (TBC1 domain family member 3)

2009-10-01  

Identity

HGNC
TBC1D3
LOCATION
17q12
LOCUSID
729873
ALIAS
PRC17,TBC1D3A,TBC1D3C,TBC1D3D,TBC1D3F,TBC1D3L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 729873
MIM: 607741
HGNC: 19031
Ensembl: ENSG00000274611

Variants:

dbSNP: 729873
ClinVar: 729873
TCGA: ENSG00000274611
COSMIC: TBC1D3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000274611ENST00000620215Q8IZP1

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
TBC/RABGAPsREACTOMER-HSA-8854214

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
335238932021TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a.18
335238932021TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a.18
284227412017Calmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells.3
288447142017Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.21
284227412017Calmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells.3
288447142017Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.21
275048052016The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.70
275048052016The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice.70
247141052014Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling.6
247141052014Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling.6
235786632013Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation.10
235786632013Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation.10
223480582012TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity.24
230295302012Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase.11
223480582012TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity.24

Citation

Dessen P

TBC1D3 (TBC1 domain family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51139/tbc1d3-(tbc1-domain-family-member-3)