Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84727
MIM: 611658
HGNC: 29522
Ensembl: ENSG00000111671
Variants:
dbSNP: 84727
ClinVar: 84727
TCGA: ENSG00000111671
COSMIC: SPSB2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000111671 | ENST00000432205 | E5RIC2 |
| ENSG00000111671 | ENST00000519357 | Q99619 |
| ENSG00000111671 | ENST00000523102 | Q99619 |
| ENSG00000111671 | ENST00000524270 | Q99619 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 29382897 | |
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 29382897 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33862200 | 2021 | Structural basis for the regulation of inducible nitric oxide synthase by the SPRY domain-containing SOCS box protein SPSB2, an E3 ubiquitin ligase. | 1 |
| 33862200 | 2021 | Structural basis for the regulation of inducible nitric oxide synthase by the SPRY domain-containing SOCS box protein SPSB2, an E3 ubiquitin ligase. | 1 |
| 31204687 | 2019 | Crystal structure of the SPRY domain of human SPSB2 in the apo state. | 1 |
| 31344133 | 2019 | SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation. | 4 |
| 31204687 | 2019 | Crystal structure of the SPRY domain of human SPSB2 in the apo state. | 1 |
| 31344133 | 2019 | SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation. | 4 |
| 28549582 | 2017 | Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction. | 4 |
| 28549582 | 2017 | Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction. | 4 |
| 19609018 | 2009 | Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential. | 16 |
| 19609018 | 2009 | Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential. | 16 |
Citation
Dessen P
SPSB2 (splA/ryanodine receptor domain and SOCS box containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2009-10-01
Online version: http://atlasgeneticsoncology.org/gene/51160/spsb2
