SPSB2 (splA/ryanodine receptor domain and SOCS box containing 2)

2009-10-01 Affiliation

Identity

HGNC

SPSB2

LOCATION

12p13.31

LOCUSID

84727

ALIAS

GRCC9,SSB2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84727
MIM: 611658
HGNC: 29522
Ensembl: ENSG00000111671

Variants:

dbSNP: 84727
ClinVar: 84727
TCGA: ENSG00000111671
COSMIC: SPSB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111671	ENST00000432205	E5RIC2
ENSG00000111671	ENST00000519357	Q99619
ENSG00000111671	ENST00000523102	Q99619
ENSG00000111671	ENST00000524270	Q99619

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA447197	Attention Deficit Disorder with Hyperactivity	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	29382897
PA450464	methylphenidate	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	29382897

References

Pubmed ID	Year	Title	Citations
33862200	2021	Structural basis for the regulation of inducible nitric oxide synthase by the SPRY domain-containing SOCS box protein SPSB2, an E3 ubiquitin ligase.	1
33862200	2021	Structural basis for the regulation of inducible nitric oxide synthase by the SPRY domain-containing SOCS box protein SPSB2, an E3 ubiquitin ligase.	1
31204687	2019	Crystal structure of the SPRY domain of human SPSB2 in the apo state.	1
31344133	2019	SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation.	4
31204687	2019	Crystal structure of the SPRY domain of human SPSB2 in the apo state.	1
31344133	2019	SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation.	4
28549582	2017	Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.	4
28549582	2017	Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.	4
19609018	2009	Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential.	16
19609018	2009	Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential.	16

Citation

Dessen P

SPSB2 (splA/ryanodine receptor domain and SOCS box containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51160/spsb2-(spla-ryanodine-receptor-domain-and-socs-box-containing-2)