EHMT1 (euchromatic histone lysine methyltransferase 1)

2009-10-01  

Identity

HGNC
EHMT1
LOCATION
9q34.3
LOCUSID
79813
ALIAS
EHMT1-IT1,EUHMTASE1,Eu-HMTase1,FP13812,GLP,GLP1,KLEFS1,KMT1D

Other Information

Locus ID:

NCBI: 79813
MIM: 607001
HGNC: 24650
Ensembl: ENSG00000181090

Variants:

dbSNP: 79813
ClinVar: 79813
TCGA: ENSG00000181090
COSMIC: EHMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181090ENST00000371394Q9H9B1
ENSG00000181090ENST00000460486A0A0D9SFX4
ENSG00000181090ENST00000460843Q9H9B1
ENSG00000181090ENST00000462484Q9H9B1
ENSG00000181090ENST00000462942A0A0C4DGF8
ENSG00000181090ENST00000465566A0A0D9SF38
ENSG00000181090ENST00000478940A0A1B0GW12
ENSG00000181090ENST00000482340A0A0D9SFM6
ENSG00000181090ENST00000486164A0A0D9SEY2
ENSG00000181090ENST00000492232A0A0D9SFG7
ENSG00000181090ENST00000493484A0A0D9SFD7
ENSG00000181090ENST00000626066A0A0D9SEQ1
ENSG00000181090ENST00000626216A0A0D9SEP2
ENSG00000181090ENST00000629335A0A1B0GUD1
ENSG00000181090ENST00000629417A0A0D9SFS4
ENSG00000181090ENST00000629808A0A0D9SER9
ENSG00000181090ENST00000630754A0A0D9SER3
ENSG00000181090ENST00000636027A0A1B0GU48
ENSG00000181090ENST00000637161A0A1B0GV09
ENSG00000181090ENST00000637261A0A1B0GW79
ENSG00000181090ENST00000637318A0A1B0GW12
ENSG00000181090ENST00000637891A0A1B0GWF6
ENSG00000181090ENST00000637949A0A1B0GTP4
ENSG00000181090ENST00000637977A0A1B0GVZ8
ENSG00000181090ENST00000638071A0A1B0GV89
ENSG00000181090ENST00000640639A0A1W2PPZ7

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841
Longevity regulating pathwayKEGGhsa04211
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through MethylationREACTOMER-HSA-6804760

References

Pubmed IDYearTitleCitations
372577682023Cell consequences of loss of function of the epigenetic factor EHMT1.1
376639292023Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression.1
378949222023Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma.1
372577682023Cell consequences of loss of function of the epigenetic factor EHMT1.1
376639292023Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression.1
378949222023Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma.1
348976782022EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma.0
349548912022EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms.20
348976782022EHMT1 promotes tumor progression and maintains stemness by regulating ALDH1A1 expression in alveolar rhabdomyosarcoma.0
349548912022EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms.20
332839492021Targeting H3K9 methyltransferase G9a and its related molecule GLP as a potential therapeutic strategy for cancer.16
342142542021EHMT1 knockdown induces apoptosis and cell cycle arrest in lung cancer cells by increasing CDKN1A expression.15
342654352021Clinical phenotypes and molecular findings in ten Chinese patients with Kleefstra Syndrome Type 1 due to EHMT1 defects.1
343576862021Kleefstra syndrome: Recurrence in siblings due to a paternal mosaic mutation.0
345884382021SPOP mutation induces DNA methylation via stabilizing GLP/G9a.17

Citation

Dessen P

EHMT1 (euchromatic histone lysine methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51162/ehmt1-(euchromatic-histone-lysine-methyltransferase-1)