PARD6A (par-6 family cell polarity regulator alpha)

2009-11-01 Affiliation

Identity

HGNC

PARD6A

LOCATION

16q22.1

LOCUSID

50855

ALIAS

PAR-6A,PAR6,PAR6C,PAR6alpha,TAX40,TIP-40

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 50855
MIM: 607484
HGNC: 15943
Ensembl: ENSG00000102981

Variants:

dbSNP: 50855
ClinVar: 50855
TCGA: ENSG00000102981
COSMIC: PARD6A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102981	ENST00000219255	Q9NPB6
ENSG00000102981	ENST00000458121	Q9NPB6
ENSG00000102981	ENST00000602551	R4GMM2

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Tight junction	KEGG	ko04530
Axon guidance	KEGG	hsa04360
Tight junction	KEGG	hsa04530
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	REACTOME	R-HSA-2173791
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
PCP/CE pathway	REACTOME	R-HSA-4086400
Asymmetric localization of PCP proteins	REACTOME	R-HSA-4608870
Cell-Cell communication	REACTOME	R-HSA-1500931
Cell junction organization	REACTOME	R-HSA-446728
Cell-cell junction organization	REACTOME	R-HSA-421270
Tight junction interactions	REACTOME	R-HSA-420029

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21170030	2011	Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.	126
18922891	2008	The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.	60
19617897	2009	Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.	60
18562307	2008	Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.	49
19667198	2009	A role for the TGFbeta-Par6 polarity pathway in breast cancer progression.	45
17057644	2006	A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells.	40
23762244	2013	A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis.	34
23249950	2013	Atypical protein kinase C phosphorylates Par6 and facilitates transforming growth factor β-induced epithelial-to-mesenchymal transition.	29
15590654	2005	Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains.	28
17586613	2007	Arterial shear stress regulates endothelial cell-directed migration, polarity, and morphology in confluent monolayers.	28

Citation

Dessen P

PARD6A (par-6 family cell polarity regulator alpha)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51178/pard6a-(par-6-family-cell-polarity-regulator-alpha)