Identity
HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
PAR-6A,PAR6,PAR6C,PAR6alpha,TAX40,TIP-40
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 50855
MIM: 607484
HGNC: 15943
Ensembl: ENSG00000102981
Variants:
dbSNP: 50855
ClinVar: 50855
TCGA: ENSG00000102981
COSMIC: PARD6A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000102981 | ENST00000219255 | Q9NPB6 |
| ENSG00000102981 | ENST00000458121 | Q9NPB6 |
| ENSG00000102981 | ENST00000602551 | R4GMM2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38954805 | 2024 | FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer. | 0 |
| 38954805 | 2024 | FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer. | 0 |
| 36542194 | 2023 | Par6 Enhances Glioma Invasion by Activating MEK/ERK Pathway Through a LIN28/let-7d Positive Feedback Loop. | 2 |
| 36542194 | 2023 | Par6 Enhances Glioma Invasion by Activating MEK/ERK Pathway Through a LIN28/let-7d Positive Feedback Loop. | 2 |
| 35379775 | 2022 | Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer. | 7 |
| 35379775 | 2022 | Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial-mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer. | 7 |
| 31914615 | 2020 | Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma. | 6 |
| 32580209 | 2020 | A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity. | 18 |
| 31914615 | 2020 | Par6 regulates cell cycle progression through enhancement of Akt/PI3K/GSK-3β signaling pathway activation in glioma. | 6 |
| 32580209 | 2020 | A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity. | 18 |
| 29696344 | 2018 | PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization. | 16 |
| 29992488 | 2018 | AhR activation protects intestinal epithelial barrier function through regulation of Par-6. | 8 |
| 30408122 | 2018 | A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization. | 4 |
| 29696344 | 2018 | PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization. | 16 |
| 29992488 | 2018 | AhR activation protects intestinal epithelial barrier function through regulation of Par-6. | 8 |
Citation
Dessen P
PARD6A (par-6 family cell polarity regulator alpha)
Atlas Genet Cytogenet Oncol Haematol. 2009-11-01
Online version: http://atlasgeneticsoncology.org/gene/51178/pard6a-(par-6-family-cell-polarity-regulator-alpha)
