Identity
HGNC
LOCATION
5p15.33
LOCUSID
ALIAS
CMD1GG,FP,MC2DN1,NDAXOA,PGL5,SDH1,SDH2,SDHF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6389
MIM: 600857
HGNC: 10680
Ensembl: ENSG00000073578
Variants:
dbSNP: 6389
ClinVar: 6389
TCGA: ENSG00000073578
COSMIC: SDHA
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36980917 | 2023 | SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update. | 4 |
| 36980917 | 2023 | SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update. | 4 |
| 33602019 | 2022 | Upregulation of SDHA inhibited proliferation, migration, and invasion of clear cell renal cell carcinoma cells via inactivation of the Wnt/β-catenin pathway. | 5 |
| 35463978 | 2022 | Subcellular Proteome Analysis Reveals Apoptotic Vulnerability of T-Cell Acute Lymphoblastic Leukemia. | 0 |
| 36232604 | 2022 | PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis. | 2 |
| 33602019 | 2022 | Upregulation of SDHA inhibited proliferation, migration, and invasion of clear cell renal cell carcinoma cells via inactivation of the Wnt/β-catenin pathway. | 5 |
| 35463978 | 2022 | Subcellular Proteome Analysis Reveals Apoptotic Vulnerability of T-Cell Acute Lymphoblastic Leukemia. | 0 |
| 36232604 | 2022 | PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis. | 2 |
| 33471299 | 2021 | A novel de novo heterozygous pathogenic variant in the SDHA gene results in childhood onset bilateral optic atrophy and cognitive impairment. | 3 |
| 33854214 | 2021 | Familial wild-type gastrointestinal stromal tumour in association with germline truncating variants in both SDHA and PALB2. | 1 |
| 34014604 | 2021 | Single nucleotide variants of succinate dehydrogenase A gene in renal cell carcinoma. | 8 |
| 33471299 | 2021 | A novel de novo heterozygous pathogenic variant in the SDHA gene results in childhood onset bilateral optic atrophy and cognitive impairment. | 3 |
| 33854214 | 2021 | Familial wild-type gastrointestinal stromal tumour in association with germline truncating variants in both SDHA and PALB2. | 1 |
| 34014604 | 2021 | Single nucleotide variants of succinate dehydrogenase A gene in renal cell carcinoma. | 8 |
| 32020209 | 2020 | Clinical significance of the molecular heterogeneity of gastrointestinal stromal tumors and related research: A systematic review. | 8 |
Citation
Dessen P
SDHA (succinate dehydrogenase complex flavoprotein subunit A)
Atlas Genet Cytogenet Oncol Haematol. 2009-11-01
Online version: http://atlasgeneticsoncology.org/gene/51180/sdha-(succinate-dehydrogenase-complex-flavoprotein-subunit-a)
