NPEPPS (aminopeptidase puromycin sensitive)

2009-11-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
AAP-S,MP100,PSA
FUSION GENES

Other Information

Locus ID:

NCBI: 9520
MIM: 606793
HGNC: 7900
Ensembl: ENSG00000141279

Variants:

dbSNP: 9520
ClinVar: 9520
TCGA: ENSG00000141279
COSMIC: NPEPPS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141279ENST00000322157P55786
ENSG00000141279ENST00000525007E9PP11
ENSG00000141279ENST00000525048H0YCQ5
ENSG00000141279ENST00000526247E9PJF9
ENSG00000141279ENST00000527298E9PPD4
ENSG00000141279ENST00000527360E9PRQ5
ENSG00000141279ENST00000527964E9PJ74
ENSG00000141279ENST00000528565H0YDG0
ENSG00000141279ENST00000530173E9PLK3
ENSG00000141279ENST00000530514E9PI82
ENSG00000141279ENST00000532729E9PPZ2
ENSG00000141279ENST00000534691E9PJY4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208292252010Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.23
251420312014Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.9
213208712011Puromycin-sensitive aminopeptidase (PSA/NPEPPS) impedes development of neuropathology in hPSA/TAU(P301L) double-transgenic mice.8
203778162009Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau.6
147065502003Analysis of conserved residues of the human puromycin-sensitive aminopeptidase.4
260787062015Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.2
253420372014[MiR-614 inhibited lung cancer cell invasion and proliferation via targeting PSA].1
194947032009Cobalt chloride-induced downregulation of puromycin-sensitive aminopeptidase suppresses the migration and invasion of PC-3 cells.0

Citation

Dessen P

NPEPPS (aminopeptidase puromycin sensitive)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51212/npepps-(aminopeptidase-puromycin-sensitive)