CXCR2 (C-X-C motif chemokine receptor 2)

2009-11-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
CD182,CDw128b,CMKAR2,IL8R2,IL8RA,IL8RB

Other Information

Locus ID:

NCBI: 3579
MIM: 146928
HGNC: 6027
Ensembl: ENSG00000180871

Variants:

dbSNP: 3579
ClinVar: 3579
TCGA: ENSG00000180871
COSMIC: CXCR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180871ENST00000318507P25025
ENSG00000180871ENST00000318507Q53PC4
ENSG00000180871ENST00000415392C9J2F9
ENSG00000180871ENST00000418878Q6LCZ7
ENSG00000180871ENST00000428565C9J1J7
ENSG00000180871ENST00000449014Q6LCZ7
ENSG00000180871ENST00000453237C9JW47
ENSG00000180871ENST00000454148C9JG19

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Cytokine-cytokine receptor interactionKEGGhsa04060
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382818542024Inhibition of chemokine receptor CXCR2 attenuates postoperative peritoneal adhesion formation.0
384075962024VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.0
384262792024CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis.0
385285332024Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease.1
386273932024CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.1
387151712024CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in the Formation and Progression of RCC with Inferior Vena Cava Tumour Thrombus.0
387244652024CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.0
382818542024Inhibition of chemokine receptor CXCR2 attenuates postoperative peritoneal adhesion formation.0
384075962024VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.0
384262792024CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis.0
385285332024Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease.1
386273932024CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.1
387151712024CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in the Formation and Progression of RCC with Inferior Vena Cava Tumour Thrombus.0
387244652024CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1-CXCR2 induced NETs.0
365772812023Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2.6

Citation

Dessen P

CXCR2 (C-X-C motif chemokine receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51226/