CDK1 (cyclin dependent kinase 1)

2010-01-01  

Identity

HGNC
LOCATION
10q21.2
LOCUSID
ALIAS
CDC2,CDC28A,P34CDC2
FUSION GENES

Other Information

Locus ID:

NCBI: 983
MIM: 116940
HGNC: 1722
Ensembl: ENSG00000170312

Variants:

dbSNP: 983
ClinVar: 983
TCGA: ENSG00000170312
COSMIC: CDK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170312ENST00000316629P06493
ENSG00000170312ENST00000316629A0A024QZJ8
ENSG00000170312ENST00000373809P06493
ENSG00000170312ENST00000373809A0A024QZJ8
ENSG00000170312ENST00000395284P06493
ENSG00000170312ENST00000448257A0A024QZP7
ENSG00000170312ENST00000519078E5RIU6
ENSG00000170312ENST00000614696A0A087WZZ9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Gap junctionKEGGko04540
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
Gap junctionKEGGhsa04540
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Cell cycle - G2/M transitionKEGGhsa_M00693
Cell cycle - G2/M transitionKEGGM00693
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
RAF-independent MAPK1/3 activationREACTOMER-HSA-112409
MAPK3 (ERK1) activationREACTOMER-HSA-110056
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
G2/M DNA replication checkpointREACTOMER-HSA-69478
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
G1/S TransitionREACTOMER-HSA-69206
G1/S-Specific TranscriptionREACTOMER-HSA-69205
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
E2F-enabled inhibition of pre-replication complex formationREACTOMER-HSA-113507
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesREACTOMER-HSA-170145
Cyclin B2 mediated eventsREACTOMER-HSA-157881
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Recruitment of NuMA to mitotic centrosomesREACTOMER-HSA-380320
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658
Condensation of Prophase ChromosomesREACTOMER-HSA-2299718
MASTL Facilitates Mitotic ProgressionREACTOMER-HSA-2465910
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Activation of NIMA Kinases NEK9, NEK6, NEK7REACTOMER-HSA-2980767
Nuclear Pore Complex (NPC) DisassemblyREACTOMER-HSA-3301854
Depolymerisation of the Nuclear LaminaREACTOMER-HSA-4419969
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Condensation of Prometaphase ChromosomesREACTOMER-HSA-2514853
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Phosphorylation of Emi1REACTOMER-HSA-176417
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176814
Phosphorylation of the APC/CREACTOMER-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointREACTOMER-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin AREACTOMER-HSA-174184
APC/C:Cdc20 mediated degradation of Cyclin BREACTOMER-HSA-174048
The role of GTSE1 in G2/M progression after G2 checkpointREACTOMER-HSA-8852276
AURKA Activation by TPX2REACTOMER-HSA-8854518
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestREACTOMER-HSA-6804114
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Expression and DegradationREACTOMER-HSA-6806003
Regulation of TP53 DegradationREACTOMER-HSA-6804757

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166122986radiotherapyChemicalClinicalAnnotationassociatedPD25054431
PA166124223pneumonitisDiseaseClinicalAnnotationassociatedPD25054431

References

Pubmed IDYearTitleCitations
200682312010Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.568
246261862014Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.305
204127692010Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis.272
211319602011CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.158
205262822010Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.143
200682302010Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis.134
127912672003Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.133
174886222007GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.114
153112852004Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.113
161982902005Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.111

Citation

Dessen P

CDK1 (cyclin dependent kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51245/cdk1-(cyclin-dependent-kinase-1)