NEU2 (neuraminidase 2)

2010-01-01  

Identity

HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
SIAL2

Other Information

Locus ID:

NCBI: 4759
MIM: 605528
HGNC: 7759
Ensembl: ENSG00000115488

Variants:

dbSNP: 4759
ClinVar: 4759
TCGA: ENSG00000115488
COSMIC: NEU2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115488ENST00000233840Q9Y3R4

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Other glycan degradationKEGGko00511
Sphingolipid metabolismKEGGko00600
Other glycan degradationKEGGhsa00511
Sphingolipid metabolismKEGGhsa00600
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
312730922020The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation.11
325759252020Desialylation of Sonic-Hedgehog by Neu2 Inhibits Its Association with Patched1 Reducing Stemness-Like Properties in Pancreatic Cancer Sphere-forming Cells.3
312730922020The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation.11
325759252020Desialylation of Sonic-Hedgehog by Neu2 Inhibits Its Association with Patched1 Reducing Stemness-Like Properties in Pancreatic Cancer Sphere-forming Cells.3
280873632017Membrane restructuring following in situ sialidase digestion of gangliosides: Complex model bilayers by synchrotron radiation reflectivity.3
280873632017Membrane restructuring following in situ sialidase digestion of gangliosides: Complex model bilayers by synchrotron radiation reflectivity.3
261933302015Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3.7
261933302015Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells-Evidence for the Physical Interaction of NEU2 and GBA3.7
250333302014Looking at human cytosolic sialidase NEU2 structural features with an interdisciplinary approach.0
250333302014Looking at human cytosolic sialidase NEU2 structural features with an interdisciplinary approach.0
239080282013Preliminary crystallographic analysis of neuraminidase N2 from a new influenza A virus.0
239080282013Preliminary crystallographic analysis of neuraminidase N2 from a new influenza A virus.0
222285462012Molecular insight into substrate recognition by human cytosolic sialidase NEU2.6
230680922012Human cytosolic sialidase NEU2-low general tissue expression but involvement in PC-3 prostate cancer cell survival.14
222285462012Molecular insight into substrate recognition by human cytosolic sialidase NEU2.6

Citation

Dessen P

NEU2 (neuraminidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51252/neu2-(neuraminidase-2)