MASP1 (MBL associated serine protease 1)

2010-01-01  

Identity

HGNC
MASP1
LOCATION
3q27.3
LOCUSID
5648
ALIAS
3MC1,CRARF,CRARF1,MAP-1,MAP1,MASP,MASP-3,MASP3,MAp44,PRSS5,RaRF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5648
MIM: 600521
HGNC: 6901
Ensembl: ENSG00000127241

Variants:

dbSNP: 5648
ClinVar: 5648
TCGA: ENSG00000127241
COSMIC: MASP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127241ENST00000169293P48740
ENSG00000127241ENST00000296280P48740
ENSG00000127241ENST00000337774P48740
ENSG00000127241ENST00000392470F8W876
ENSG00000127241ENST00000392472P48740
ENSG00000127241ENST00000392475C9JMA2
ENSG00000127241ENST00000425937C9JLU5
ENSG00000127241ENST00000439271C9J1C7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Creation of C4 and C2 activatorsREACTOMER-HSA-166786
Lectin pathway of complement activationREACTOMER-HSA-166662
Ficolins bind to repetitive carbohydrate structures on the target cell surfaceREACTOMER-HSA-2855086
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging by Class A ReceptorsREACTOMER-HSA-3000480

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
358490322023Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.13
358490322023Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.13
352933112022MicroRNA-122-5p regulates coagulation and inflammation through MASP1 and HO-1 genes.4
354834502022Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.2
360321722022Complement lectin pathway components MBL and MASP-1 promote haemostasis upon vessel injury in a microvascular bleeding model.5
361264992022Identification of substrates of MBL Associated Serine Protease-1 (MASP-1) from human plasma using N-terminomics strategy.0
361662162022MASP1 Gene Polymorphism and MASP-3 Serum Levels in Patients with Chronic Chagas Disease.0
361967212022Comprehensive analysis of the immune and prognostic implication of MASP1 in stomach adenocarcinoma.1
352933112022MicroRNA-122-5p regulates coagulation and inflammation through MASP1 and HO-1 genes.4
354834502022Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.2
360321722022Complement lectin pathway components MBL and MASP-1 promote haemostasis upon vessel injury in a microvascular bleeding model.5
361264992022Identification of substrates of MBL Associated Serine Protease-1 (MASP-1) from human plasma using N-terminomics strategy.0
361662162022MASP1 Gene Polymorphism and MASP-3 Serum Levels in Patients with Chronic Chagas Disease.0
361967212022Comprehensive analysis of the immune and prognostic implication of MASP1 in stomach adenocarcinoma.1
337809462021MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis.6

Citation

Dessen P

MASP1 (MBL associated serine protease 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51261/masp1-(mbl-associated-serine-protease-1)