Identity
HGNC
LOCATION
17q12
LOCUSID
ALIAS
CRK7,CRKR,CRKRS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51755
MIM: 615514
HGNC: 24224
Ensembl: ENSG00000167258
Variants:
dbSNP: 51755
ClinVar: 51755
TCGA: ENSG00000167258
COSMIC: CDK12
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38335502 | 2024 | ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features. | 1 |
| 38481813 | 2024 | Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects. | 0 |
| 38736108 | 2024 | Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer. | 1 |
| 38838276 | 2024 | Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease. | 0 |
| 38335502 | 2024 | ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features. | 1 |
| 38481813 | 2024 | Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects. | 0 |
| 38736108 | 2024 | Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer. | 1 |
| 38838276 | 2024 | Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease. | 0 |
| 36734254 | 2023 | Prognostic and clinicopathological value of CDK12 mutation in prostate cancer: a meta-analysis. | 0 |
| 36951936 | 2023 | CDK12 Promotes the Proliferation, Migration, and Angiogenesis of Gastric Carcinoma via Activating the PI3K/AKT/mTOR Signaling Pathway. | 0 |
| 37026485 | 2023 | CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1. | 8 |
| 37113064 | 2023 | Comparison of circulating tumor DNA between African American and Caucasian patients with metastatic castrate-resistant prostate cancer post-abiraterone and/or enzalutamide. | 3 |
| 37205756 | 2023 | CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation. | 3 |
| 37357968 | 2023 | CDK12 alterations and ARID1A mutations are predictors of poor prognosis and therapeutic targets in high-grade salivary gland carcinoma: analysis of the National Genomic Profiling Database. | 1 |
| 37517598 | 2023 | CDK12 loss inhibits cell proliferation by regulating TBK1 in non-small cell lung cancer cells. | 1 |
Citation
Dessen P
CDK12 (cyclin dependent kinase 12)
Atlas Genet Cytogenet Oncol Haematol. 2010-01-01
Online version: http://atlasgeneticsoncology.org/gene/51267/cdk12-(cyclin-dependent-kinase-12)
