TIGIT (T cell immunoreceptor with Ig and ITIM domains)

2010-01-01  

Identity

HGNC
TIGIT
LOCATION
3q13.31
LOCUSID
201633
ALIAS
VSIG9,VSTM3,WUCAM

Other Information

Locus ID:

NCBI: 201633
MIM: 612859
HGNC: 26838
Ensembl: ENSG00000181847

Variants:

dbSNP: 201633
ClinVar: 201633
TCGA: ENSG00000181847
COSMIC: TIGIT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181847ENST00000383671Q495A1
ENSG00000181847ENST00000461158C9J0B0
ENSG00000181847ENST00000481065A0A0C4DGA4
ENSG00000181847ENST00000484319C9JZW6
ENSG00000181847ENST00000486257Q495A1

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514

References

Pubmed IDYearTitleCitations
377494092024Decreased expression of TIGIT on CD14 + monocytes correlates with clinical features and laboratory parameters of patients with primary Sjögren's syndrome.1
379525202024LAG3 and TIGIT Expression on Tumor-Infiltrating Lymphocytes in Cutaneous Melanoma.1
382169492024The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling.0
383052862024Ectopic Expression of TIGIT in Lung Adenocarcinoma and Its Clinical Significance.0
384275562024Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity.1
384615412024FCRL3 expression is upregulated and closely correlates with TIGIT expression in regulatory T cells of patients with systemic lupus erythematosus.0
388522892024Targeting the dynamic transcriptional landscape of Treg subpopulations in pancreatic ductal adenocarcinoma: Insights from single-cell RNA sequencing analysis with a focus on CTLA4 and TIGIT.0
388687762024TIGIT(+)Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre.0
377494092024Decreased expression of TIGIT on CD14 + monocytes correlates with clinical features and laboratory parameters of patients with primary Sjögren's syndrome.1
379525202024LAG3 and TIGIT Expression on Tumor-Infiltrating Lymphocytes in Cutaneous Melanoma.1
382169492024The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling.0
383052862024Ectopic Expression of TIGIT in Lung Adenocarcinoma and Its Clinical Significance.0
384275562024Combining TIGIT Blockade with MDSC Inhibition Hinders Breast Cancer Bone Metastasis by Activating Antitumor Immunity.1
384615412024FCRL3 expression is upregulated and closely correlates with TIGIT expression in regulatory T cells of patients with systemic lupus erythematosus.0
388522892024Targeting the dynamic transcriptional landscape of Treg subpopulations in pancreatic ductal adenocarcinoma: Insights from single-cell RNA sequencing analysis with a focus on CTLA4 and TIGIT.0

Citation

Dessen P

TIGIT (T cell immunoreceptor with Ig and ITIM domains)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51271/tigit-(t-cell-immunoreceptor-with-ig-and-itim-domains)