Identity
HGNC
LOCATION
22q13.31
LOCUSID
ALIAS
LK4,dA59H18.2,dA59H18.3,hCERK
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64781
MIM: 610307
HGNC: 19256
Ensembl: ENSG00000100422
Variants:
dbSNP: 64781
ClinVar: 64781
TCGA: ENSG00000100422
COSMIC: CERK
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100422 | ENST00000216264 | Q8TCT0 |
| ENSG00000100422 | ENST00000216264 | A0A024R4U8 |
| ENSG00000100422 | ENST00000443629 | F8WFD8 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38556546 | 2024 | Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2. | 1 |
| 38556546 | 2024 | Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2. | 1 |
| 36410675 | 2023 | Ceramide kinase confers tamoxifen resistance in estrogen receptor-positive breast cancer by altering sphingolipid metabolism. | 2 |
| 36410675 | 2023 | Ceramide kinase confers tamoxifen resistance in estrogen receptor-positive breast cancer by altering sphingolipid metabolism. | 2 |
| 36309544 | 2022 | Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance. | 4 |
| 36309544 | 2022 | Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance. | 4 |
| 33859296 | 2021 | Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells. | 19 |
| 33859296 | 2021 | Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells. | 19 |
| 32056304 | 2020 | MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle. | 13 |
| 32092937 | 2020 | Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt. | 18 |
| 32112978 | 2020 | Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells. | 10 |
| 32056304 | 2020 | MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle. | 13 |
| 32092937 | 2020 | Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt. | 18 |
| 32112978 | 2020 | Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells. | 10 |
| 30502084 | 2019 | Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells. | 8 |
Citation
Dessen P
CERK (ceramide kinase)
Atlas Genet Cytogenet Oncol Haematol. 2010-01-01
Online version: http://atlasgeneticsoncology.org/gene/51284/cerk-(ceramide-kinase)
