CERK (ceramide kinase)

2010-01-01  

Identity

HGNC
CERK
LOCATION
22q13.31
LOCUSID
64781
ALIAS
LK4,dA59H18.2,dA59H18.3,hCERK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64781
MIM: 610307
HGNC: 19256
Ensembl: ENSG00000100422

Variants:

dbSNP: 64781
ClinVar: 64781
TCGA: ENSG00000100422
COSMIC: CERK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100422ENST00000216264Q8TCT0
ENSG00000100422ENST00000216264A0A024R4U8
ENSG00000100422ENST00000443629F8WFD8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

References

Pubmed IDYearTitleCitations
385565462024Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.1
385565462024Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.1
364106752023Ceramide kinase confers tamoxifen resistance in estrogen receptor-positive breast cancer by altering sphingolipid metabolism.2
364106752023Ceramide kinase confers tamoxifen resistance in estrogen receptor-positive breast cancer by altering sphingolipid metabolism.2
363095442022Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance.4
363095442022Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance.4
338592962021Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells.19
338592962021Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells.19
320563042020MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.13
320929372020Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt.18
321129782020Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells.10
320563042020MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.13
320929372020Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt.18
321129782020Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells.10
305020842019Ceramide kinase regulates the migration of bone marrow-derived mesenchymal stem cells.8

Citation

Dessen P

CERK (ceramide kinase)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51284/cerk-(ceramide-kinase)