CDK11A (cyclin dependent kinase 11A)

2010-01-01  

Identity

HGNC
CDK11A
LOCATION
1p36.33
LOCUSID
728642
ALIAS
CDC2L2,CDC2L3,CDK11-p110,CDK11-p46,CDK11-p58,PITSLRE,p58GTA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 728642
MIM: 116951
HGNC: 1730
Ensembl: ENSG00000008128

Variants:

dbSNP: 728642
ClinVar: 728642
TCGA: ENSG00000008128
COSMIC: CDK11A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008128ENST00000356200Q5QPR4
ENSG00000008128ENST00000357760Q5QPR3
ENSG00000008128ENST00000358779Q9UQ88
ENSG00000008128ENST00000378633Q9UQ88
ENSG00000008128ENST00000378638Q5QPR4
ENSG00000008128ENST00000401096Q5QPQ9
ENSG00000008128ENST00000404249Q9UQ88
ENSG00000008128ENST00000460465J3KS35
ENSG00000008128ENST00000479362E9PFJ2
ENSG00000008128ENST00000509982E7ESP2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
333098572021Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11(p110).15
333098572021Galactosyltransferase B4GALT1 confers chemoresistance in pancreatic ductal adenocarcinomas by upregulating N-linked glycosylation of CDK11(p110).15
307227252019CDK11(p110) plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.9
307227252019CDK11(p110) plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.9
270497272016The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.29
270497272016The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.29
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.21
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.21
191222082009Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation.13
192458112009Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.33
195207722009CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.8
191222082009Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation.13
192458112009Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.33
195207722009CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.8
171772672007Genetic variations of the CDC2L2 gene are associated with type 2 diabetes in a Han Chinese cohort.1

Citation

Dessen P

CDK11A (cyclin dependent kinase 11A)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51286/cdk11a-(cyclin-dependent-kinase-11a)