KMT5A (lysine methyltransferase 5A)

2015-11-01  

Identity

HGNC
KMT5A
LOCATION
12q24.31
LOCUSID
387893
ALIAS
PR-Set7,PR/SET07,SET07,SET8,SETD8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 387893
MIM: 607240
HGNC: 29489
Ensembl: ENSG00000183955

Variants:

dbSNP: 387893
ClinVar: 387893
TCGA: ENSG00000183955
COSMIC: KMT5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183955ENST00000330479A0A0C4DFR3
ENSG00000183955ENST00000402868Q9NQR1
ENSG00000183955ENST00000437502C9JKQ0
ENSG00000183955ENST00000437519F8WC45

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Condensation of Prophase ChromosomesREACTOMER-HSA-2299718
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through MethylationREACTOMER-HSA-6804760

References

Pubmed IDYearTitleCitations
383010492024Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.1
385650812024Lysine Methyltransferase 5A Promotes the Progression of Growth Hormone Pituitary Neuroendocrine Tumors through the Wnt/β-Catenin Signaling Pathway.0
389630442024Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer.0
383010492024Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.1
385650812024Lysine Methyltransferase 5A Promotes the Progression of Growth Hormone Pituitary Neuroendocrine Tumors through the Wnt/β-Catenin Signaling Pathway.0
389630442024Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer.0
369214922023SETD8 promotes glycolysis in colorectal cancer via regulating HIF1α/HK2 axis.0
369214922023SETD8 promotes glycolysis in colorectal cancer via regulating HIF1α/HK2 axis.0
348469462022SET8, a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects.4
348946062022Integrative bioinformatics analysis the clinical value of KMT5A in different subtypes of lung cancer.0
354491312022KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling.10
361490502022KMT5A Knockdown Suppresses Osteosarcoma Cell Proliferation and Metastasis Through Ꞵ-Catenin Signalling.3
348469462022SET8, a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects.4
348946062022Integrative bioinformatics analysis the clinical value of KMT5A in different subtypes of lung cancer.0
354491312022KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling.10

Citation

Dessen P

KMT5A (lysine methyltransferase 5A)

Atlas Genet Cytogenet Oncol Haematol. 2015-11-01

Online version: http://atlasgeneticsoncology.org/gene/51291/kmt5a-(lysine-methyltransferase-5a)