MKRN1 (makorin ring finger protein 1)

2010-01-01 Affiliation

Identity

HGNC

MKRN1

LOCATION

7q34

LOCUSID

23608

ALIAS

RNF61

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23608
MIM: 607754
HGNC: 7112
Ensembl: ENSG00000133606

Variants:

dbSNP: 23608
ClinVar: 23608
TCGA: ENSG00000133606
COSMIC: MKRN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133606	ENST00000255977	Q9UHC7
ENSG00000133606	ENST00000443720	Q9UHC7
ENSG00000133606	ENST00000463142	H7C4H5
ENSG00000133606	ENST00000467513	C9J031
ENSG00000133606	ENST00000471104	C9IY57
ENSG00000133606	ENST00000473444	C9IZP5
ENSG00000133606	ENST00000474576	Q9UHC7
ENSG00000133606	ENST00000475180	H7C588
ENSG00000133606	ENST00000480552	C9JYI0
ENSG00000133606	ENST00000494939	C9JYX8
ENSG00000133606	ENST00000495305	F8WAS8
ENSG00000133606	ENST00000496169	F8WBJ4
ENSG00000133606	ENST00000498535	F8WEY8

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

References

Pubmed ID	Year	Title	Citations
38480859	2024	MKRN1 regulates the expression profiles and transcription factor activity in HeLa cells inhibition suppresses cervical cancer cell progression.	0
38480859	2024	MKRN1 regulates the expression profiles and transcription factor activity in HeLa cells inhibition suppresses cervical cancer cell progression.	0
36938725	2023	MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53.	1
37620897	2023	MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation.	2
36938725	2023	MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53.	1
37620897	2023	MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation.	2
34398495	2021	Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls.	7
34398495	2021	Gastrointestinal stromal tumors with BRAF gene fusions. A report of two cases showing low or absent KIT expression resulting in diagnostic pitfalls.	7
31640799	2019	The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.	20
31640799	2019	The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.	20
29142133	2018	Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.	9
29713058	2018	Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling.	16
29142133	2018	Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.	9
29713058	2018	Ubiquitylation and degradation of adenomatous polyposis coli by MKRN1 enhances Wnt/β-catenin signaling.	16
26817873	2016	Makorin Ring Finger Protein 1 as Adjunctive Marker in Liquid-based Cervical Cytology.	1

Citation

Dessen P

MKRN1 (makorin ring finger protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51299