EFNA4 (ephrin A4)

2010-01-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
EFL4,EPLG4,LERK4
FUSION GENES

Other Information

Locus ID:

NCBI: 1945
MIM: 601380
HGNC: 3224
Ensembl: ENSG00000243364

Variants:

dbSNP: 1945
ClinVar: 1945
TCGA: ENSG00000243364
COSMIC: EFNA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243364ENST00000359751P52798
ENSG00000243364ENST00000368409P52798
ENSG00000243364ENST00000427683P52798

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165405162006Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis.74
206437272010Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis.62
198286932009An impaired transendothelial migration potential of chronic lymphocytic leukemia (CLL) cells can be linked to ephrin-A4 expression.13
188197112009Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells.11
250709152014Ephrin-A3 and ephrin-A4 contribute to microglia-induced angiogenesis in brain endothelial cells.8
236868142013Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.4
273741802016EphrinA4 plays a critical role in α4 and αL mediated survival of human CLL cells during extravasation.3
120308492002Characterization of the human ephrin-A4 promoter.2
200717902010Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome.2

Citation

Dessen P

EFNA4 (ephrin A4)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51304/efna4-(ephrin-a4)