MYO5A (myosin VA)

2010-01-01  

Identity

HGNC
MYO5A
LOCATION
15q21.2
LOCUSID
4644
ALIAS
GS1,MYH12,MYO5,MYR12
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4644
MIM: 160777
HGNC: 7602
Ensembl: ENSG00000197535

Variants:

dbSNP: 4644
ClinVar: 4644
TCGA: ENSG00000197535
COSMIC: MYO5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197535ENST00000356338Q9Y4I1
ENSG00000197535ENST00000358212F8W6H6
ENSG00000197535ENST00000399228Q9UES5
ENSG00000197535ENST00000399229E7ERV5
ENSG00000197535ENST00000399231Q9Y4I1
ENSG00000197535ENST00000399233F8WE88
ENSG00000197535ENST00000553916G3V394
ENSG00000197535ENST00000556196G3V3C9
ENSG00000197535ENST00000568914O95317
ENSG00000197535ENST00000613858A0A087WY00

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381297842023MYO5A overexpression promotes invasion and correlates with low lymphocyte infiltration in head and neck squamous carcinoma.0
381297842023MYO5A overexpression promotes invasion and correlates with low lymphocyte infiltration in head and neck squamous carcinoma.0
349354142022Modeling myosin Va liposome transport through actin filament networks reveals a percolation threshold that modulates transport properties.0
349354142022Modeling myosin Va liposome transport through actin filament networks reveals a percolation threshold that modulates transport properties.0
337272502021LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.25
346808752021MYO5A Frameshift Variant in a Miniature Dachshund with Coat Color Dilution and Neurological Defects Resembling Human Griscelli Syndrome Type 1.8
337272502021LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.25
346808752021MYO5A Frameshift Variant in a Miniature Dachshund with Coat Color Dilution and Neurological Defects Resembling Human Griscelli Syndrome Type 1.8
324965612020LUZP1 and the tumor suppressor EPLIN modulate actin stability to restrict primary cilia formation.14
327357282020Identification of three predictors of gastric cancer progression and prognosis.9
324965612020LUZP1 and the tumor suppressor EPLIN modulate actin stability to restrict primary cilia formation.14
327357282020Identification of three predictors of gastric cancer progression and prognosis.9
307332782019Myosin Va interacts with the exosomal protein spermine synthase.1
307332782019Myosin Va interacts with the exosomal protein spermine synthase.1
292988892018A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress.8

Citation

Dessen P

MYO5A (myosin VA)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51309/myo5a-(myosin-va)