MLXIPL (MLX interacting protein like)

2010-02-01  

Identity

HGNC
MLXIPL
LOCATION
7q11.23
LOCUSID
51085
ALIAS
CHREBP,MIO,MLX,MONDOB,WBSCR14,WS-bHLH,bHLHd14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51085
MIM: 605678
HGNC: 12744
Ensembl: ENSG00000009950

Variants:

dbSNP: 51085
ClinVar: 51085
TCGA: ENSG00000009950
COSMIC: MLXIPL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000009950ENST00000313375Q9NP71
ENSG00000009950ENST00000345114Q9NP71
ENSG00000009950ENST00000354613Q9NP71
ENSG00000009950ENST00000414749Q9NP71
ENSG00000009950ENST00000429400Q9NP71
ENSG00000009950ENST00000434326A0A0C4DG26
ENSG00000009950ENST00000453275C9JDF5
ENSG00000009950ENST00000456640H7C1V3

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
PKA-mediated phosphorylation of key metabolic factorsREACTOMER-HSA-163358
AMPK inhibits chREBP transcriptional activation activityREACTOMER-HSA-163680
PP2A-mediated dephosphorylation of key metabolic factorsREACTOMER-HSA-163767
ChREBP activates metabolic gene expressionREACTOMER-HSA-163765
Insulin resistanceKEGGhsa04931

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33744PRKAA1GenePathwayassociated22722338
PA33745PRKAA2GenePathwayassociated22722338
PA33746PRKAB1GenePathwayassociated22722338
PA33747PRKAB2GenePathwayassociated22722338
PA33751PRKAG1GenePathwayassociated22722338
PA33752PRKAG2GenePathwayassociated22722338
PA33753PRKAG3GenePathwayassociated22722338

References

Pubmed IDYearTitleCitations
381013972024ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits.2
381283832024Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy.0
383318482024Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity.1
386687312024A genome-first approach to variants in MLXIPL and their association with hepatic steatosis and plasma lipids.1
381013972024ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits.2
381283832024Knockdown of ChREBP ameliorates retinal microvascular endothelial cell injury and angiogenic responses in diabetic retinopathy.0
383318482024Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity.1
386687312024A genome-first approach to variants in MLXIPL and their association with hepatic steatosis and plasma lipids.1
364134062023HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.5
368099792023MLXIPL promotes the migration, invasion, and glycolysis of hepatocellular carcinoma cells by phosphorylation of mTOR.4
369232222023New insights into the inter-organ crosstalk mediated by ChREBP.1
370555472023The role of ChREBP in carbohydrate sensing and NAFLD development.15
364134062023HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.5
368099792023MLXIPL promotes the migration, invasion, and glycolysis of hepatocellular carcinoma cells by phosphorylation of mTOR.4
369232222023New insights into the inter-organ crosstalk mediated by ChREBP.1

Citation

Dessen P

MLXIPL (MLX interacting protein like)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51326/mlxipl-(mlx-interacting-protein-like)