Identity
HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
KCa2.3,SK3,SKCA3,ZLS3,hSK3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3782
MIM: 602983
HGNC: 6292
Ensembl: ENSG00000143603
Variants:
dbSNP: 3782
ClinVar: 3782
TCGA: ENSG00000143603
COSMIC: KCNN3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000143603 | ENST00000271915 | Q9UGI6 |
| ENSG00000143603 | ENST00000358505 | Q9UGI6 |
| ENSG00000143603 | ENST00000361147 | Q9UGI6 |
| ENSG00000143603 | ENST00000618040 | A0A087WYJ0 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Insulin secretion | KEGG | hsa04911 |
| Neuronal System | REACTOME | R-HSA-112316 |
| Potassium Channels | REACTOME | R-HSA-1296071 |
| Ca2+ activated K+ channels | REACTOME | R-HSA-1296052 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36502918 | 2023 | Preferential formation of human heteromeric SK2:SK3 channels limits homomeric SK channel assembly and function. | 2 |
| 36502918 | 2023 | Preferential formation of human heteromeric SK2:SK3 channels limits homomeric SK channel assembly and function. | 2 |
| 35488306 | 2022 | The role of SK3 in progesterone-induced inhibition of human fallopian tubal contraction. | 2 |
| 35488306 | 2022 | The role of SK3 in progesterone-induced inhibition of human fallopian tubal contraction. | 2 |
| 33310041 | 2021 | HDAC2-dependent remodeling of K(Ca)2.2 (KCNN2) and K(Ca)2.3 (KCNN3) K(+) channels in atrial fibrillation with concomitant heart failure. | 7 |
| 33594261 | 2021 | Syndromic disorders caused by gain-of-function variants in KCNH1, KCNK4, and KCNN3-a subgroup of K(+) channelopathies. | 16 |
| 33310041 | 2021 | HDAC2-dependent remodeling of K(Ca)2.2 (KCNN2) and K(Ca)2.3 (KCNN3) K(+) channels in atrial fibrillation with concomitant heart failure. | 7 |
| 33594261 | 2021 | Syndromic disorders caused by gain-of-function variants in KCNH1, KCNK4, and KCNN3-a subgroup of K(+) channelopathies. | 16 |
| 32640738 | 2020 | Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating EMT-Activator Zeb1 and SK3 Channel Expression. | 12 |
| 32640738 | 2020 | Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating EMT-Activator Zeb1 and SK3 Channel Expression. | 12 |
| 30922569 | 2019 | Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF study. | 6 |
| 31155282 | 2019 | Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca(2+)-Activated K(+) Channel SK3 Cause Zimmermann-Laband Syndrome. | 26 |
| 31486252 | 2019 | Liability of the voltage-gated potassium channel KCNN3 repeat polymorphism to acute oxaliplatin-induced peripheral neurotoxicity. | 5 |
| 30922569 | 2019 | Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF study. | 6 |
| 31155282 | 2019 | Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca(2+)-Activated K(+) Channel SK3 Cause Zimmermann-Laband Syndrome. | 26 |
Citation
Dessen P
KCNN3 (potassium calcium-activated channel subfamily N member 3)
Atlas Genet Cytogenet Oncol Haematol. 2010-02-01
Online version: http://atlasgeneticsoncology.org/gene/51331/kcnn3-(potassium-calcium-activated-channel-subfamily-n-member-3)
