Identity
HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
JHDM2A,JHMD2A,JMJD1,JMJD1A,TSGA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55818
MIM: 611512
HGNC: 20815
Ensembl: ENSG00000115548
Variants:
dbSNP: 55818
ClinVar: 55818
TCGA: ENSG00000115548
COSMIC: KDM3A
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HDMs demethylate histones | REACTOME | R-HSA-3214842 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38165573 | 2024 | Knockout of KDM3A in MDA-MB-231 breast cancer cells inhibits tumor malignancy and promotes apoptosis. | 0 |
| 38165573 | 2024 | Knockout of KDM3A in MDA-MB-231 breast cancer cells inhibits tumor malignancy and promotes apoptosis. | 0 |
| 33888871 | 2022 | Downregulation of miR-335 exhibited an oncogenic effect via promoting KDM3A/YAP1 networks in clear cell renal cell carcinoma. | 8 |
| 35020958 | 2022 | Histone demethylase JMJD1A in cancer progression and therapeutic resistance. | 5 |
| 35579678 | 2022 | Histone demethylase JHDM2A participates in the repair of arsenic-induced DNA damage in L-02 cells by regulating DDB2. | 0 |
| 36094735 | 2022 | KDM3A promotes oral squamous cell carcinoma cell proliferation and invasion via H3K9me2 demethylation-activated DCLK1. | 0 |
| 33888871 | 2022 | Downregulation of miR-335 exhibited an oncogenic effect via promoting KDM3A/YAP1 networks in clear cell renal cell carcinoma. | 8 |
| 35020958 | 2022 | Histone demethylase JMJD1A in cancer progression and therapeutic resistance. | 5 |
| 35579678 | 2022 | Histone demethylase JHDM2A participates in the repair of arsenic-induced DNA damage in L-02 cells by regulating DDB2. | 0 |
| 36094735 | 2022 | KDM3A promotes oral squamous cell carcinoma cell proliferation and invasion via H3K9me2 demethylation-activated DCLK1. | 0 |
| 33486545 | 2021 | microRNA-155-3p attenuates intervertebral disc degeneration via inhibition of KDM3A and HIF1α. | 6 |
| 34171978 | 2021 | KDM1A and KDM3A promote tumor growth by upregulating cell cycle-associated genes in pancreatic cancer. | 6 |
| 34235877 | 2021 | Spermatozoa retrieval in azoospermia and expression profile of JMJD1A, TNP2, and PRM2 in a subset of the Karachi population. | 6 |
| 34321328 | 2021 | KDM3A regulates alternative splicing of cell-cycle genes following DNA damage. | 8 |
| 34350711 | 2021 | Overexpression of let-7d explains down-regulated KDM3A and ENO2 in the pathogenesis of preeclampsia. | 5 |
Citation
Dessen P
KDM3A (lysine demethylase 3A)
Atlas Genet Cytogenet Oncol Haematol. 2010-02-01
Online version: http://atlasgeneticsoncology.org/gene/51339
