KDM3A (lysine demethylase 3A)

2010-02-01  

Identity

HGNC
KDM3A
LOCATION
2p11.2
LOCUSID
55818
ALIAS
JHDM2A,JHMD2A,JMJD1,JMJD1A,TSGA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55818
MIM: 611512
HGNC: 20815
Ensembl: ENSG00000115548

Variants:

dbSNP: 55818
ClinVar: 55818
TCGA: ENSG00000115548
COSMIC: KDM3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115548ENST00000312912Q9Y4C1
ENSG00000115548ENST00000409064Q9Y4C1
ENSG00000115548ENST00000409556Q9Y4C1
ENSG00000115548ENST00000427678C9J7Q7
ENSG00000115548ENST00000441719F8WE62
ENSG00000115548ENST00000452034C9JC73

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

References

Pubmed IDYearTitleCitations
198582932010Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth.137
189845852008The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.122
187130682008Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.119
185381292008Hypoxia upregulates the histone demethylase JMJD1A via HIF-1.78
226453022012Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A.76
247426402014The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1.47
200426012010Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.44
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
259485112015JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.37
208231412010Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells.36

Citation

Dessen P

KDM3A (lysine demethylase 3A)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51339/kdm3a-(lysine-demethylase-3a)