FTO (FTO alpha-ketoglutarate dependent dioxygenase)

2010-02-01  

Identity

HGNC
FTO
LOCATION
16q12.2
LOCUSID
79068
ALIAS
ALKBH9,BMIQ14,GDFD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79068
MIM: 610966
HGNC: 24678
Ensembl: ENSG00000140718

Variants:

dbSNP: 79068
ClinVar: 79068
TCGA: ENSG00000140718
COSMIC: FTO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140718ENST00000268349X6R3I0
ENSG00000140718ENST00000431610Q9C0B1
ENSG00000140718ENST00000460382Q9C0B1
ENSG00000140718ENST00000463855Q9C0B1
ENSG00000140718ENST00000464071F8WCB8
ENSG00000140718ENST00000471389Q9C0B1
ENSG00000140718ENST00000563011A0A1B0GTI3
ENSG00000140718ENST00000612285A0A1B0GUY7
ENSG00000140718ENST00000636218A0A1B0GTC5
ENSG00000140718ENST00000636491A0A1B0GUC3
ENSG00000140718ENST00000636992A0A1B0GTY1
ENSG00000140718ENST00000637001A0A1B0GU26
ENSG00000140718ENST00000637049A0A1B0GTY5
ENSG00000140718ENST00000637062A0A1B0GTZ8
ENSG00000140718ENST00000637562A0A1B0GV98
ENSG00000140718ENST00000637845A0A1B0GTC3
ENSG00000140718ENST00000637969A0A1B0GVH5
ENSG00000140718ENST00000640179F8WCB8

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Damage ReversalREACTOMER-HSA-73942
Reversal of alkylation damage by DNA dioxygenasesREACTOMER-HSA-73943

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406954Weight gainDiseaseMultilinkAnnotationassociated24279860
PA164779048interferon alfa-2a, recombinantChemicalClinicalAnnotationassociatedPD25367448
PA164783990interferon alfa-2b, recombinantChemicalClinicalAnnotationassociatedPD25367448
PA166048887Irritable Bowel SyndromeDiseaseClinicalAnnotationassociatedPD27558924
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD32451486
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD
PA444773LeukopeniaDiseaseClinicalAnnotationassociatedPD27558924
PA446863Hepatitis C, ChronicDiseaseClinicalAnnotationassociatedPD25367448
PA447230HIVDiseaseClinicalAnnotationassociatedPD25367448
PA448073ethanolChemicalClinicalAnnotationassociatedPD32451486
PA448499atenololChemicalClinicalAnnotationassociatedPD
PA448515azathioprineChemicalClinicalAnnotationassociatedPD27558924
PA450379mercaptopurineChemicalClinicalAnnotationassociatedPD27558924
PA451241ribavirinChemicalClinicalAnnotationassociatedPD25367448

References

Pubmed IDYearTitleCitations
377349102024Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis.3
378173302024FTO variation and early frontostriatal brain development in children.0
379726992024Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma.2
380488622024Exosome-shuttled FTO from BM-MSCs contributes to cancer malignancy and chemoresistance in acute myeloid leukemia by inducing m6A-demethylation: A nano-based investigation.2
380712632024FTO is a major genetic link between breast cancer, obesity, and diabetes.1
381976792024Evaluation of the role of FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms in type 1 diabetes and their relation to obesity.0
382004412024RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer.0
382327992024Fat mass and obesity-associated (FTO) gene is essential for insulin secretion and β-cell function: In vitro studies using INS-1 cells and human pancreatic islets.0
382458152024FTO protein regulates the TGF-β signalling pathway through RNA N6-methyladenosine modification to induce unexplained recurrent spontaneous abortion.0
382706432024The m(6)A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance.1
383809572024FTO promotes the progression of retinoblastoma through YTHDF2-dependent N6-methyladenosine modification in E2F3.0
384423742024The rs1477196 SNP of the FTO Gene is Associated with Primary Knee Osteoarthritis in a Female Population from Northern Mexico.0
385541572024circFTO from M2 macrophage-derived small extracellular vesicles (sEV) enhances NSCLC malignancy by regulation miR-148a-3pPDK4 axis.0
385565862024Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.1
385567262024Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different FTO Genotypes.0

Citation

Dessen P

FTO (FTO alpha-ketoglutarate dependent dioxygenase)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51352