Identity
HGNC
LOCATION
16q12.2
LOCUSID
ALIAS
ALKBH9,BMIQ14,GDFD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79068
MIM: 610966
HGNC: 24678
Ensembl: ENSG00000140718
Variants:
dbSNP: 79068
ClinVar: 79068
TCGA: ENSG00000140718
COSMIC: FTO
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| DNA Repair | REACTOME | R-HSA-73894 |
| DNA Damage Reversal | REACTOME | R-HSA-73942 |
| Reversal of alkylation damage by DNA dioxygenases | REACTOME | R-HSA-73943 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406954 | Weight gain | Disease | MultilinkAnnotation | associated | 24279860 | ||
| PA164779048 | interferon alfa-2a, recombinant | Chemical | ClinicalAnnotation | associated | PD | 25367448 | |
| PA164783990 | interferon alfa-2b, recombinant | Chemical | ClinicalAnnotation | associated | PD | 25367448 | |
| PA166048887 | Irritable Bowel Syndrome | Disease | ClinicalAnnotation | associated | PD | 27558924 | |
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | 32451486 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | ||
| PA444773 | Leukopenia | Disease | ClinicalAnnotation | associated | PD | 27558924 | |
| PA446863 | Hepatitis C, Chronic | Disease | ClinicalAnnotation | associated | PD | 25367448 | |
| PA447230 | HIV | Disease | ClinicalAnnotation | associated | PD | 25367448 | |
| PA448073 | ethanol | Chemical | ClinicalAnnotation | associated | PD | 32451486 | |
| PA448499 | atenolol | Chemical | ClinicalAnnotation | associated | PD | ||
| PA448515 | azathioprine | Chemical | ClinicalAnnotation | associated | PD | 27558924 | |
| PA450379 | mercaptopurine | Chemical | ClinicalAnnotation | associated | PD | 27558924 | |
| PA451241 | ribavirin | Chemical | ClinicalAnnotation | associated | PD | 25367448 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37734910 | 2024 | Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis. | 3 |
| 37817330 | 2024 | FTO variation and early frontostriatal brain development in children. | 0 |
| 37972699 | 2024 | Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma. | 2 |
| 38048862 | 2024 | Exosome-shuttled FTO from BM-MSCs contributes to cancer malignancy and chemoresistance in acute myeloid leukemia by inducing m6A-demethylation: A nano-based investigation. | 2 |
| 38071263 | 2024 | FTO is a major genetic link between breast cancer, obesity, and diabetes. | 1 |
| 38197679 | 2024 | Evaluation of the role of FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms in type 1 diabetes and their relation to obesity. | 0 |
| 38200441 | 2024 | RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer. | 0 |
| 38232799 | 2024 | Fat mass and obesity-associated (FTO) gene is essential for insulin secretion and β-cell function: In vitro studies using INS-1 cells and human pancreatic islets. | 0 |
| 38245815 | 2024 | FTO protein regulates the TGF-β signalling pathway through RNA N6-methyladenosine modification to induce unexplained recurrent spontaneous abortion. | 0 |
| 38270643 | 2024 | The m(6)A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance. | 1 |
| 38380957 | 2024 | FTO promotes the progression of retinoblastoma through YTHDF2-dependent N6-methyladenosine modification in E2F3. | 0 |
| 38442374 | 2024 | The rs1477196 SNP of the FTO Gene is Associated with Primary Knee Osteoarthritis in a Female Population from Northern Mexico. | 0 |
| 38554157 | 2024 | circFTO from M2 macrophage-derived small extracellular vesicles (sEV) enhances NSCLC malignancy by regulation miR-148a-3pPDK4 axis. | 0 |
| 38556586 | 2024 | Fat mass and obesity-associated protein (FTO) mediated m(6)A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay. | 1 |
| 38556726 | 2024 | Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different FTO Genotypes. | 0 |
Citation
Dessen P
FTO (FTO alpha-ketoglutarate dependent dioxygenase)
Atlas Genet Cytogenet Oncol Haematol. 2010-02-01
Online version: http://atlasgeneticsoncology.org/gene/51352/fto-(fto-alpha-ketoglutarate-dependent-dioxygenase)
