Identity
HGNC
LOCATION
14q23.2
LOCUSID
ALIAS
EDMD5,KASH2,NUA,NUANCE,Nesp2,Nesprin-2,SYNE-2,TROPH
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23224
MIM: 608442
HGNC: 17084
Ensembl: ENSG00000054654
Variants:
dbSNP: 23224
ClinVar: 23224
TCGA: ENSG00000054654
COSMIC: SYNE2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Cell Cycle | REACTOME | R-HSA-1640170 |
| Meiosis | REACTOME | R-HSA-1500620 |
| Meiotic synapsis | REACTOME | R-HSA-1221632 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36930595 | 2023 | Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders. | 3 |
| 36959177 | 2023 | Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression. | 7 |
| 36930595 | 2023 | Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders. | 3 |
| 36959177 | 2023 | Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression. | 7 |
| 34558192 | 2022 | Silencing of Nesprin-2 inhibits the differentiation of myofibroblasts from fibroblasts induced by mechanical stretch. | 4 |
| 34558192 | 2022 | Silencing of Nesprin-2 inhibits the differentiation of myofibroblasts from fibroblasts induced by mechanical stretch. | 4 |
| 33472039 | 2021 | Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins. | 6 |
| 33686165 | 2021 | The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. | 9 |
| 33472039 | 2021 | Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins. | 6 |
| 33686165 | 2021 | The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal. | 9 |
| 32184094 | 2020 | A novel SYNE2 mutation identified by whole exome sequencing in a Korean family with Emery-Dreifuss muscular dystrophy. | 2 |
| 32184094 | 2020 | A novel SYNE2 mutation identified by whole exome sequencing in a Korean family with Emery-Dreifuss muscular dystrophy. | 2 |
| 31144711 | 2019 | SPAG4L/SPAG4Lβ interacts with Nesprin2 to participate in the meiosis of spermatogenesis. | 5 |
| 31578382 | 2019 | Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle. | 12 |
| 31144711 | 2019 | SPAG4L/SPAG4Lβ interacts with Nesprin2 to participate in the meiosis of spermatogenesis. | 5 |
Citation
Dessen P
SYNE2 (spectrin repeat containing nuclear envelope protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-02-01
Online version: http://atlasgeneticsoncology.org/gene/51353/syne2-(spectrin-repeat-containing-nuclear-envelope-protein-2)
