WARS1 (tryptophanyl-tRNA synthetase 1)

2010-02-01  

Identity

HGNC
WARS1
LOCATION
14q32.2
LOCUSID
7453
ALIAS
GAMMA-2,HMN9,IFI53,IFP53,WARS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7453
MIM: 191050
HGNC: 12729
Ensembl: ENSG00000140105

Variants:

dbSNP: 7453
ClinVar: 7453
TCGA: ENSG00000140105
COSMIC: WARS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140105ENST00000344102P23381
ENSG00000140105ENST00000355338P23381
ENSG00000140105ENST00000355338A0A024R6K8
ENSG00000140105ENST00000358655P23381
ENSG00000140105ENST00000392882P23381
ENSG00000140105ENST00000392882A0A024R6K8
ENSG00000140105ENST00000553395G3V3Y5
ENSG00000140105ENST00000553413G3V5W1
ENSG00000140105ENST00000553524G3V3P2
ENSG00000140105ENST00000553545G3V4C7
ENSG00000140105ENST00000553581G3V5H5
ENSG00000140105ENST00000553769G3V4N8
ENSG00000140105ENST00000553934P78534
ENSG00000140105ENST00000554509G3V4N0
ENSG00000140105ENST00000554601H0YJP3
ENSG00000140105ENST00000554605G3V313
ENSG00000140105ENST00000554772G3V3X0
ENSG00000140105ENST00000554820G3V2C0
ENSG00000140105ENST00000555031G3V2F2
ENSG00000140105ENST00000555410G3V2Y7
ENSG00000140105ENST00000555813G3V4S4
ENSG00000140105ENST00000556209G3V339
ENSG00000140105ENST00000556295G3V3R3
ENSG00000140105ENST00000556338G3V423
ENSG00000140105ENST00000556435G3V5U1
ENSG00000140105ENST00000556504G3V3H8
ENSG00000140105ENST00000556645P23381
ENSG00000140105ENST00000556660G3V3S7
ENSG00000140105ENST00000556695G3V3R3
ENSG00000140105ENST00000556698G3V227
ENSG00000140105ENST00000556783G3V4A3
ENSG00000140105ENST00000557135P23381
ENSG00000140105ENST00000557135A0A024R6K8
ENSG00000140105ENST00000557297G3V456
ENSG00000140105ENST00000557347G3V4Q0
ENSG00000140105ENST00000557722G3V277
ENSG00000140105ENST00000627608G3V4Q0

Pathways

PathwaySourceExternal ID
Aminoacyl-tRNA biosynthesisKEGGko00970
Aminoacyl-tRNA biosynthesisKEGGhsa00970
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGhsa_M00359
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGM00359
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716

References

Pubmed IDYearTitleCitations
381775282024Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis.0
382478712024Tryptophanyl-Transfer RNA Synthetase Is Involved in a Negative Feedback Loop Mitigating Interferon-γ-Induced Gene Expression.0
381775282024Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis.0
382478712024Tryptophanyl-Transfer RNA Synthetase Is Involved in a Negative Feedback Loop Mitigating Interferon-γ-Induced Gene Expression.0
375673232023Exploring the role of tryptophanyl-tRNA synthetase and associations with inflammatory markers and clinical outcomes in COVID-19 patients: A case-control study.1
378951332023Tryptophan-Starved Human Cells Overexpressing Tryptophanyl-tRNA Synthetase Enhance High-Affinity Tryptophan Uptake via Enzymatic Production of Tryptophanyl-AMP.1
375673232023Exploring the role of tryptophanyl-tRNA synthetase and associations with inflammatory markers and clinical outcomes in COVID-19 patients: A case-control study.1
378951332023Tryptophan-Starved Human Cells Overexpressing Tryptophanyl-tRNA Synthetase Enhance High-Affinity Tryptophan Uptake via Enzymatic Production of Tryptophanyl-AMP.1
357900482022WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly.7
358153452022Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function.7
357900482022WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly.7
358153452022Biallelic variants in WARS1 cause a highly variable neurodevelopmental syndrome and implicate a critical exon for normal auditory function.7
337549092021Identification of Prognostic RBPs in Osteosarcoma.6
337549092021Identification of Prognostic RBPs in Osteosarcoma.6
310334972020Expression of Indoleamine 2, 3-dioxygenase 1 (IDO1) and Tryptophanyl-tRNA Synthetase (WARS) in Gastric Cancer Molecular Subtypes.18

Citation

Dessen P

WARS1 (tryptophanyl-tRNA synthetase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51355/wars1-(tryptophanyl-trna-synthetase-1)