SIRT3 (sirtuin 3)

2010-03-01  

Identity

HGNC
SIRT3
LOCATION
11p15.5
LOCUSID
23410
ALIAS
SIR2L3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23410
MIM: 604481
HGNC: 14931
Ensembl: ENSG00000142082

Variants:

dbSNP: 23410
ClinVar: 23410
TCGA: ENSG00000142082
COSMIC: SIRT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142082ENST00000382743Q9NTG7
ENSG00000142082ENST00000524564E9PN58
ENSG00000142082ENST00000525237E9PR48
ENSG00000142082ENST00000525319E9PK80
ENSG00000142082ENST00000525776E9PM52
ENSG00000142082ENST00000526854E9PJS6
ENSG00000142082ENST00000528469E9PNA0
ENSG00000142082ENST00000529055E9PIT6
ENSG00000142082ENST00000529382Q9NTG7
ENSG00000142082ENST00000529937B7WNN4
ENSG00000142082ENST00000530067E9PIT6
ENSG00000142082ENST00000532837E9PIT6
ENSG00000142082ENST00000532956E9PM75

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373545302024The protective mechanism of SIRT3 and potential therapy in acute kidney injury.0
376516732024Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation.11
382331932024Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis.3
382427482024Context-dependent role of SIRT3 in cancer.3
382557922024Reduced SIRT1 and SIRT3 and Lower Antioxidant Capacity of Seminal Plasma Is Associated with Shorter Sperm Telomere Length in Oligospermic Men.1
382617672024SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process.3
382858902024Sirtuin3 promotes the degradation of hepatic Z alpha-1 antitrypsin through lipophagy.1
383959902024Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11.2
384069702024Sirtuin 3 regulates astrocyte activation by reducing Notch1 signaling after status epilepticus.0
385174472024Sirt3 Protects Retinal Pigment Epithelial Cells From High Glucose-Induced Injury by Promoting Mitophagy Through the AMPK/mTOR/ULK1 Pathway.0
385482462024SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant phenotypes.1
385561092024Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.0
386263282024SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells.0
373545302024The protective mechanism of SIRT3 and potential therapy in acute kidney injury.0
376516732024Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation.11

Citation

Dessen P

SIRT3 (sirtuin 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51385/sirt3-(sirtuin-3)