GINS1 (GINS complex subunit 1)

2010-03-01  

Identity

HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
IMD55,PSF1
FUSION GENES

Other Information

Locus ID:

NCBI: 9837
MIM: 610608
HGNC: 28980
Ensembl: ENSG00000101003

Variants:

dbSNP: 9837
ClinVar: 9837
TCGA: ENSG00000101003
COSMIC: GINS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101003ENST00000262460Q14691

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
GINS complexKEGGhsa_M00286
GINS complexKEGGM00286
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378243722024Transcription Factor E2F1 Enhances Hepatocellular Carcinoma Cell Proliferation and Stemness by Activating GINS1.1
384684642024GINS1 promotes ZEB1-mediated epithelial-mesenchymal transition and tumor metastasis via β-catenin signaling in hepatocellular carcinoma.1
388803242024GINS1 promotes the initiation and progression of bladder cancer by activating the AKT/mTOR/c-Myc signaling pathway.0
378243722024Transcription Factor E2F1 Enhances Hepatocellular Carcinoma Cell Proliferation and Stemness by Activating GINS1.1
384684642024GINS1 promotes ZEB1-mediated epithelial-mesenchymal transition and tumor metastasis via β-catenin signaling in hepatocellular carcinoma.1
388803242024GINS1 promotes the initiation and progression of bladder cancer by activating the AKT/mTOR/c-Myc signaling pathway.0
364690092023A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma Is Mediated through Transcriptional Activation of GINS1.6
364690092023A Novel Tumor-Promoting Role for Nuclear Factor IX in Glioblastoma Is Mediated through Transcriptional Activation of GINS1.6
358960112022Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.4
358960112022Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.4
339726842021MALAT1 modulated FOXP3 ubiquitination then affected GINS1 transcription and drived NSCLC proliferation.15
348521352021Up-regulation of GINS1 highlighted a good diagnostic and prognostic potential of survival in three different subtypes of human cancer.17
339726842021MALAT1 modulated FOXP3 ubiquitination then affected GINS1 transcription and drived NSCLC proliferation.15
348521352021Up-regulation of GINS1 highlighted a good diagnostic and prognostic potential of survival in three different subtypes of human cancer.17
304650752019Induced expression of GINS complex is an essential step for reactivation of quiescent stem-like tumor cells within the peri-necrotic niche in human glioblastoma.12

Citation

Dessen P

GINS1 (GINS complex subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51386/gins1