UGT1A (UDP glucuronosyltransferase family 1 member A complex locus)

2010-03-01 Affiliation

Identity

HGNC

UGT1A

LOCATION

2q37.1

LOCUSID

7361

ALIAS

GNT1,UGT,UGT1,UGT1A@

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7361
HGNC: 12529

Variants:

dbSNP: 7361
ClinVar: 7361
COSMIC: UGT1A

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA166123346	bilirubin	Chemical	ClinicalAnnotation	associated	PK		25778466
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	25778466
PA446443	Liver Failure, Acute	Disease	ClinicalAnnotation	associated		PD
PA448015	acetaminophen	Chemical	ClinicalAnnotation	associated	PK	PD
PA450085	irinotecan	Chemical	ClinicalAnnotation	associated		PD	25778466

References

Pubmed ID	Year	Title	Citations
37328712	2023	The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis.	1
37328712	2023	The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis.	1
33432840	2021	Regulation of uridine diphosphate-glucuronosyltransferase 1A expression by miRNA-214-5p and miRNA-486-3p.	2
33432840	2021	Regulation of uridine diphosphate-glucuronosyltransferase 1A expression by miRNA-214-5p and miRNA-486-3p.	2
29172698	2018	Regulation of UGT1A expression by miR-298 in human livers from the Han Chinese population and in human cell lines.	2
29210323	2018	Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis.	12
29172698	2018	Regulation of UGT1A expression by miR-298 in human livers from the Han Chinese population and in human cell lines.	2
29210323	2018	Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis.	12
28049773	2017	Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism.	12
28294511	2017	UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population.	7
28300668	2017	Protective effects of coffee against oxidative stress induced by the tobacco carcinogen benzo[α]pyrene.	11
28049773	2017	Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism.	12
28294511	2017	UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population.	7
28300668	2017	Protective effects of coffee against oxidative stress induced by the tobacco carcinogen benzo[α]pyrene.	11
26010150	2015	Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients.	9

Citation

Dessen P

UGT1A (UDP glucuronosyltransferase family 1 member A complex locus)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51398/ugt1a-(udp-glucuronosyltransferase-family-1-member-a-complex-locus)