TRIM22 (tripartite motif containing 22)

2010-03-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
GPSTAF50,RNF94,STAF50
FUSION GENES

Other Information

Locus ID:

NCBI: 10346
MIM: 606559
HGNC: 16379
Ensembl: ENSG00000132274

Variants:

dbSNP: 10346
ClinVar: 10346
TCGA: ENSG00000132274
COSMIC: TRIM22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132274ENST00000379965Q8IYM9
ENSG00000132274ENST00000414641C9JIU5
ENSG00000132274ENST00000414897H7BZD3
ENSG00000132274ENST00000425490C9J060
ENSG00000132274ENST00000429063H7C376
ENSG00000132274ENST00000444844H7C262
ENSG00000132274ENST00000450670H7C2K0
ENSG00000132274ENST00000454828C9JWC5

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381999812024TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.0
382752982024The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8.3
381999812024TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.0
382752982024The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8.3
372585772023TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.4
372585772023TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.4
356360152022TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.37
356741572022Role of TRIM22 in ulcerative colitis and its underlying mechanisms.1
359464622022FOXC1‑mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast‑like synoviocytes in rheumatoid arthritis via NF‑κB signaling pathway.3
360289022022On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.8
361704532022TRIM22 actives PI3K/Akt/mTOR pathway to promote psoriasis through enhancing cell proliferation and inflammation and inhibiting autophagy.2
356360152022TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.37
356741572022Role of TRIM22 in ulcerative colitis and its underlying mechanisms.1
359464622022FOXC1‑mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast‑like synoviocytes in rheumatoid arthritis via NF‑κB signaling pathway.3
360289022022On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.8

Citation

Dessen P

TRIM22 (tripartite motif containing 22)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51401/js/humanGenome