RBCK1 (RANBP2-type and C3HC4-type zinc finger containing 1)

2010-03-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
C20orf18,HOIL-1,HOIL1,PBMEI,PGBM1,RBCK2,RNF54,UBCE7IP3,XAP3,XAP4,ZRANB4
FUSION GENES

Other Information

Locus ID:

NCBI: 10616
MIM: 610924
HGNC: 15864
Ensembl: ENSG00000125826

Variants:

dbSNP: 10616
ClinVar: 10616
TCGA: ENSG00000125826
COSMIC: RBCK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125826ENST00000353660Q9BYM8
ENSG00000125826ENST00000356286Q9BYM8
ENSG00000125826ENST00000382181A6PVK0
ENSG00000125826ENST00000382214G3XAG9
ENSG00000125826ENST00000400247A6PVJ5
ENSG00000125826ENST00000411647Q5JWR1
ENSG00000125826ENST00000414880H0Y4S7
ENSG00000125826ENST00000415942B4DML5
ENSG00000125826ENST00000441733A6PVJ7
ENSG00000125826ENST00000475269A6PVJ6
ENSG00000125826ENST00000640614A6PVK0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905

References

Pubmed IDYearTitleCitations
382146062024RBCK1 overexpression is associated with immune cell infiltration and poor prognosis in hepatocellular carcinoma.0
386322772024HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes.0
387632082024E3 ubiquitin ligase RBCK1 confers ferroptosis resistance in pancreatic cancer by facilitating MFN2 degradation.0
382146062024RBCK1 overexpression is associated with immune cell infiltration and poor prognosis in hepatocellular carcinoma.0
386322772024HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes.0
387632082024E3 ubiquitin ligase RBCK1 confers ferroptosis resistance in pancreatic cancer by facilitating MFN2 degradation.0
367021062023RBCK1 Overexpression Attenuates Inflammation and Mobility of Derp1-Induced Nasal Mucosal Cells by Downregulating NLRP3.0
379768372023Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN.1
367021062023RBCK1 Overexpression Attenuates Inflammation and Mobility of Derp1-Induced Nasal Mucosal Cells by Downregulating NLRP3.0
379768372023Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN.1
351744712022Regulation of PTEN and ovarian cancer progression by an E3 ubiquitin ligase RBCK1.3
352747592022HOIL-1 ubiquitin ligase activity targets unbranched glucosaccharides and is required to prevent polyglucosan accumulation.28
362808292022RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis.5
364738472022RBCK1 regulates the progression of ER-positive breast cancer through the HIF1α signaling.5
351744712022Regulation of PTEN and ovarian cancer progression by an E3 ubiquitin ligase RBCK1.3

Citation

Dessen P

RBCK1 (RANBP2-type and C3HC4-type zinc finger containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51404/rbck1-(ranbp2-type-and-c3hc4-type-zinc-finger-containing-1)