Identity
HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
CSDD1,LIN-28,LIN28,ZCCHC1,lin-28A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79727
MIM: 611043
HGNC: 15986
Ensembl: ENSG00000131914
Variants:
dbSNP: 79727
ClinVar: 79727
TCGA: ENSG00000131914
COSMIC: LIN28A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000131914 | ENST00000254231 | Q9H9Z2 |
| ENSG00000131914 | ENST00000326279 | Q9H9Z2 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Transcriptional regulation of pluripotent stem cells | REACTOME | R-HSA-452723 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38167913 | 2024 | Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells. | 0 |
| 38216964 | 2024 | Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28. | 2 |
| 38430033 | 2024 | Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression. | 2 |
| 38612395 | 2024 | Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway. | 0 |
| 38636252 | 2024 | GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-κB/NLRP3 inflammasome pathway. | 1 |
| 38729326 | 2024 | Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury. | 0 |
| 38167913 | 2024 | Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells. | 0 |
| 38216964 | 2024 | Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28. | 2 |
| 38430033 | 2024 | Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression. | 2 |
| 38612395 | 2024 | Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway. | 0 |
| 38636252 | 2024 | GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-κB/NLRP3 inflammasome pathway. | 1 |
| 38729326 | 2024 | Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury. | 0 |
| 36436798 | 2023 | Lin28a induced mitochondrial dysfunction in human granulosa cells via suppressing LARS2 expression. | 5 |
| 36649308 | 2023 | LIN28 expression and function in medulloblastoma. | 2 |
| 36658347 | 2023 | Analysis of LIN28A variants in patients with Parkinson's disease. | 0 |
Citation
Dessen P
LIN28A (lin-28 homolog A)
Atlas Genet Cytogenet Oncol Haematol. 2010-04-01
Online version: http://atlasgeneticsoncology.org/gene/51415/lin28a-(lin-28-homolog-a)
