Identity
HGNC
LOCATION
12q24.22
LOCUSID
ALIAS
FBW6,FBW8,FBX29,FBXO29,FBXW6
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26259
MIM: 609073
HGNC: 13597
Ensembl: ENSG00000174989
Variants:
dbSNP: 26259
ClinVar: 26259
TCGA: ENSG00000174989
COSMIC: FBXW8
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000174989 | ENST00000309909 | A0A499FIY5 |
| ENSG00000174989 | ENST00000455858 | Q8N3Y1 |
| ENSG00000174989 | ENST00000652555 | Q8N3Y1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36400179 | 2023 | Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans. | 4 |
| 36400179 | 2023 | Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans. | 4 |
| 33742524 | 2021 | FBXW8 regulates G1 and S phases of cell cycle progression by restricting β-TrCP1 function. | 1 |
| 33742524 | 2021 | FBXW8 regulates G1 and S phases of cell cycle progression by restricting β-TrCP1 function. | 1 |
| 29310837 | 2018 | Assessment of a FBXW8 frameshift mutation, c.1312_1313delGT, in breast cancer patients and controls from Central Europe. | 1 |
| 29310837 | 2018 | Assessment of a FBXW8 frameshift mutation, c.1312_1313delGT, in breast cancer patients and controls from Central Europe. | 1 |
| 25790475 | 2015 | Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated. | 8 |
| 25790475 | 2015 | Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated. | 8 |
| 24362026 | 2014 | The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. | 23 |
| 24973709 | 2014 | MicroRNA-218 inhibits the proliferation of human choriocarcinoma JEG-3 cell line by targeting Fbxw8. | 10 |
| 24362026 | 2014 | The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. | 23 |
| 24973709 | 2014 | MicroRNA-218 inhibits the proliferation of human choriocarcinoma JEG-3 cell line by targeting Fbxw8. | 10 |
| 22524683 | 2012 | Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restriction? | 3 |
| 23029530 | 2012 | Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase. | 11 |
| 22524683 | 2012 | Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restriction? | 3 |
Citation
Dessen P
FBXW8 (F-box and WD repeat domain containing 8)
Atlas Genet Cytogenet Oncol Haematol. 2010-04-01
Online version: http://atlasgeneticsoncology.org/gene/51418/fbxw8-(f-box-and-wd-repeat-domain-containing-8)
