PON2 (paraoxonase 2)

2010-05-01  

Identity

HGNC
PON2
LOCATION
7q21.3
LOCUSID
5445
ALIAS
-

Other Information

Locus ID:

NCBI: 5445
MIM: 602447
HGNC: 9205
Ensembl: ENSG00000105854

Variants:

dbSNP: 5445
ClinVar: 5445
TCGA: ENSG00000105854
COSMIC: PON2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105854ENST00000222572Q15165
ENSG00000105854ENST00000433091Q15165
ENSG00000105854ENST00000446142A0A2Q2SAK4
ENSG00000105854ENST00000455123G3XAK4
ENSG00000105854ENST00000469926A0A0J9YXU7
ENSG00000105854ENST00000478801A0A0J9YVW3
ENSG00000105854ENST00000483292A0A0J9YYJ1
ENSG00000105854ENST00000490778A0A0J9YYF3
ENSG00000105854ENST00000491069A0A0J9YXM1
ENSG00000105854ENST00000493290A0A0J9YYF0
ENSG00000105854ENST00000632034A0A0J9YXM1
ENSG00000105854ENST00000633192A0A0J9YXF2
ENSG00000105854ENST00000633531Q15165

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of 5-eicosatetraenoic acidsREACTOMER-HSA-2142688

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD
PA452229antidepressantsChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
383974452024Contribution of the Paraoxonase-2 Enzyme to Cancer Cell Metabolism and Phenotypes.1
388933102024The Human Paraoxonase 2: An Optimized Procedure for Refolding and Stabilization Facilitates Enzyme Analyses and a Proteomics Approach.0
383974452024Contribution of the Paraoxonase-2 Enzyme to Cancer Cell Metabolism and Phenotypes.1
388933102024The Human Paraoxonase 2: An Optimized Procedure for Refolding and Stabilization Facilitates Enzyme Analyses and a Proteomics Approach.0
366535842023Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation.2
368405002023PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting the CANX/NOX4 signaling pathway.1
368975492023Paraoxonase-2 is upregulated in triple negative breast cancer and contributes to tumor progression and chemoresistance.14
366535842023Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation.2
368405002023PON2 ameliorates Ang II-induced cardiomyocyte injury by targeting the CANX/NOX4 signaling pathway.1
368975492023Paraoxonase-2 is upregulated in triple negative breast cancer and contributes to tumor progression and chemoresistance.14
347104872022Paraoxonase 2 protects against the CML mediated mitochondrial dysfunction through modulating JNK pathway in human retinal cells.2
350924162022Insights into the role of paraoxonase 2 in human pathophysiology.6
352863302022Airway epithelial Paraoxonase-2 in obese asthma.2
354606102022Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis.0
360766612022Association of Paraoxonase-2 (C1053G) Gene Polymorphism with the Expression of Paraoxonase-2 Gene in Patients of Ischemic Stroke - A Pilot Study in Indian Population.1

Citation

Dessen P

PON2 (paraoxonase 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51467/pon2-(paraoxonase-2)