USP17L2 (ubiquitin specific peptidase 17 like family member 2)

2010-05-01  

Identity

HGNC
USP17L2
LOCATION
8p23.1
LOCUSID
377630
ALIAS
DUB-3,DUB3,USP17

Other Information

Locus ID:

NCBI: 377630
MIM: 610186
HGNC: 34434
Ensembl: ENSG00000223443

Variants:

dbSNP: 377630
ClinVar: 377630
TCGA: ENSG00000223443
COSMIC: USP17L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000223443ENST00000333796Q6R6M4

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376525262023Clinicopathological Significance of DUB3 Expression in Non-small Cell Lung Cancer and Relationship Between DUB3 Expression and LATS1 Expression.0
376525262023Clinicopathological Significance of DUB3 Expression in Non-small Cell Lung Cancer and Relationship Between DUB3 Expression and LATS1 Expression.0
359272362022NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3.2
360406422022USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.4
359272362022NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3.2
360406422022USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cells.4
306286802019Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis.10
307184312019MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.43
307782002019DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer.43
309351082019Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells.22
306286802019Whole exome sequencing identifies hemizygous deletions in the UGT2B28 and USP17L2 genes in a three‑generation family with endometriosis.10
307184312019MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.43
307782002019DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer.43
309351082019Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells.22
300571992018DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.78

Citation

Dessen P

USP17L2 (ubiquitin specific peptidase 17 like family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51473/usp17l2-(ubiquitin-specific-peptidase-17-like-family-member-2)