Identity
HGNC
LOCATION
6p22.3
LOCUSID
ALIAS
AD022,EAP2,EAPII,TTRAP,dJ30M3.3,hTDP2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51567
MIM: 605764
HGNC: 17768
Ensembl: ENSG00000111802
Variants:
dbSNP: 51567
ClinVar: 51567
TCGA: ENSG00000111802
COSMIC: TDP2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000111802 | ENST00000341060 | X6R5A3 |
| ENSG00000111802 | ENST00000378198 | O95551 |
| ENSG00000111802 | ENST00000378198 | A0A384MDM5 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| DNA Repair | REACTOME | R-HSA-73894 |
| DNA Double-Strand Break Repair | REACTOME | R-HSA-5693532 |
| Nonhomologous End-Joining (NHEJ) | REACTOME | R-HSA-5693571 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37558815 | 2023 | Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia. | 1 |
| 37558815 | 2023 | Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia. | 1 |
| 34606976 | 2021 | A novel non-sense mutation in TDP2 causes spinocerebellar ataxia autosomal recessive 23 accompanied by bilateral upward gaze; report of a case and review of the literature. | 2 |
| 34606976 | 2021 | A novel non-sense mutation in TDP2 causes spinocerebellar ataxia autosomal recessive 23 accompanied by bilateral upward gaze; report of a case and review of the literature. | 2 |
| 32023921 | 2020 | Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation. | 3 |
| 32277721 | 2020 | TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands. | 4 |
| 32356875 | 2020 | Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. | 9 |
| 32460231 | 2020 | Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3'-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1). | 10 |
| 32651480 | 2020 | Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23). | 3 |
| 32653827 | 2020 | Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases. | 9 |
| 33378676 | 2020 | DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks. | 24 |
| 32023921 | 2020 | Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation. | 3 |
| 32277721 | 2020 | TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands. | 4 |
| 32356875 | 2020 | Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. | 9 |
| 32460231 | 2020 | Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3'-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1). | 10 |
Citation
Dessen P
TDP2 (tyrosyl-DNA phosphodiesterase 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-05-01
Online version: http://atlasgeneticsoncology.org/gene/51498/tdp2-(tyrosyl-dna-phosphodiesterase-2)
