FYB1 (FYN binding protein 1)

2010-05-01  

Identity

HGNC
FYB1
LOCATION
5p13.1
LOCUSID
2533
ALIAS
ADAP,FYB,PRO0823,SLAP-130,SLAP130,THC3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2533
MIM: 602731
HGNC: 4036
Ensembl: ENSG00000082074

Variants:

dbSNP: 2533
ClinVar: 2533
TCGA: ENSG00000082074
COSMIC: FYB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082074ENST00000351578O15117
ENSG00000082074ENST00000506557D6RAE8
ENSG00000082074ENST00000509072D6RC38
ENSG00000082074ENST00000510188D6RFJ5
ENSG00000082074ENST00000512138D6RER7
ENSG00000082074ENST00000512982O15117
ENSG00000082074ENST00000515010O15117
ENSG00000082074ENST00000646045O15117
ENSG00000082074ENST00000646444A0A2R8YEE1

Pathways

PathwaySourceExternal ID
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Generation of second messenger moleculesREACTOMER-HSA-202433
Cell-Cell communicationREACTOMER-HSA-1500931
Signal regulatory protein (SIRP) family interactionsREACTOMER-HSA-391160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
348820572022FYB methylation in peripheral blood as a potential marker for the early-stage lung cancer: a case-control study in Chinese population.1
348820572022FYB methylation in peripheral blood as a potential marker for the early-stage lung cancer: a case-control study in Chinese population.1
342953392021The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events.10
342953392021The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events.10
303053052018ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters.12
303053052018ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters.12
291271482017Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.6
291271482017Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.6
272587832016Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.1
273355012016ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion.8
272587832016Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.1
273355012016ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion.8
257299322015Short Communication FYB polymorphisms in Brazilian patients with type I diabetes mellitus and autoimmune polyglandular syndrome type III.1
258761822015Deleterious mutation in the FYB gene is associated with congenital autosomal recessive small-platelet thrombocytopenia.20
259094592015The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.12

Citation

Dessen P

FYB1 (FYN binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51500/