Identity
HGNC
LOCATION
15q13.2
LOCUSID
ALIAS
CHRNA7,CHRNA7-DR1,D-10,NACHRA7
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 89832
MIM: 609756
HGNC: 15781
Ensembl: ENSG00000166664
Variants:
dbSNP: 89832
ClinVar: 89832
TCGA: ENSG00000166664
COSMIC: CHRFAM7A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000166664 | ENST00000299847 | Q494W8 |
| ENSG00000166664 | ENST00000397827 | A0A0A6YYA8 |
| ENSG00000166664 | ENST00000401522 | A0A0A6YYA8 |
| ENSG00000166664 | ENST00000562729 | H3BPP0 |
Expression (GTEx)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38382524 | 2024 | Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation. | 2 |
| 38472514 | 2024 | Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech. | 0 |
| 38382524 | 2024 | Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation. | 2 |
| 38472514 | 2024 | Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech. | 0 |
| 36479618 | 2023 | Up-regulation of the human-specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy. | 4 |
| 36627169 | 2023 | Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours. | 6 |
| 37655479 | 2023 | Human-specific CHRFAM7A primes macrophages for a heightened pro-inflammatory response at the earlier stage of inflammation. | 0 |
| 37749098 | 2023 | An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies. | 1 |
| 36479618 | 2023 | Up-regulation of the human-specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy. | 4 |
| 36627169 | 2023 | Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours. | 6 |
| 37655479 | 2023 | Human-specific CHRFAM7A primes macrophages for a heightened pro-inflammatory response at the earlier stage of inflammation. | 0 |
| 37749098 | 2023 | An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies. | 1 |
| 35408823 | 2022 | The Human-Restricted Isoform of the α7 nAChR, CHRFAM7A: A Double-Edged Sword in Neurological and Inflammatory Disorders. | 11 |
| 35408823 | 2022 | The Human-Restricted Isoform of the α7 nAChR, CHRFAM7A: A Double-Edged Sword in Neurological and Inflammatory Disorders. | 11 |
| 31583530 | 2021 | Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. | 24 |
Citation
Dessen P
CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion)
Atlas Genet Cytogenet Oncol Haematol. 2010-06-01
Online version: http://atlasgeneticsoncology.org/gene/51508/chrfam7a-(chrna7-(exons-5-10)-and-fam7a-(exons-a-e)-fusion)
