RFWD3 (ring finger and WD repeat domain 3)

2010-06-01  

Identity

HGNC
LOCATION
16q23.1
LOCUSID
ALIAS
FANCW,RNF201
FUSION GENES

Other Information

Locus ID:

NCBI: 55159
MIM: 614151
HGNC: 25539
Ensembl: ENSG00000168411

Variants:

dbSNP: 55159
ClinVar: 55159
TCGA: ENSG00000168411
COSMIC: RFWD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168411ENST00000361070Q6PCD5
ENSG00000168411ENST00000571750Q6PCD5
ENSG00000168411ENST00000572337I3L284
ENSG00000168411ENST00000572990I3L2T2
ENSG00000168411ENST00000575113I3L4I5
ENSG00000168411ENST00000576652I3L299

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370366932023RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks.4
370366932023RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks.4
358302502022Systematic analysis on expression quantitative trait loci identifies a novel regulatory variant in ring finger and WD repeat domain 3 associated with prognosis of pancreatic cancer.2
358302502022Systematic analysis on expression quantitative trait loci identifies a novel regulatory variant in ring finger and WD repeat domain 3 associated with prognosis of pancreatic cancer.2
333210942021The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.35
333210942021The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.35
315711612020Identification of an E3 ligase-encoding gene RFWD3 in non-small cell lung cancer.8
323918712020E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells.11
329024052020Down-regulation of RFWD3 inhibits cancer cells proliferation and migration in gastric carcinoma.6
330448902020The E3 ligase RFWD3 stabilizes ORC in a p53-dependent manner.2
315711612020Identification of an E3 ligase-encoding gene RFWD3 in non-small cell lung cancer.8
323918712020E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells.11
329024052020Down-regulation of RFWD3 inhibits cancer cells proliferation and migration in gastric carcinoma.6
330448902020The E3 ligase RFWD3 stabilizes ORC in a p53-dependent manner.2
285756572017RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.49

Citation

Dessen P

RFWD3 (ring finger and WD repeat domain 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51515/rfwd3-(ring-finger-and-wd-repeat-domain-3)