RFWD3 (ring finger and WD repeat domain 3)

2010-06-01  

Identity

HGNC
LOCATION
16q23.1
LOCUSID
ALIAS
FANCW,RNF201
FUSION GENES

Other Information

Locus ID:

NCBI: 55159
MIM: 614151
HGNC: 25539
Ensembl: ENSG00000168411

Variants:

dbSNP: 55159
ClinVar: 55159
TCGA: ENSG00000168411
COSMIC: RFWD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168411ENST00000361070Q6PCD5
ENSG00000168411ENST00000571750Q6PCD5
ENSG00000168411ENST00000572337I3L284
ENSG00000168411ENST00000572990I3L2T2
ENSG00000168411ENST00000575113I3L4I5
ENSG00000168411ENST00000576652I3L299

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
285756582017RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination.36
264740682015RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.33
201730982010RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.28
215582762011RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.24
285756572017RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.18
215049062011E3 ligase RFWD3 participates in replication checkpoint control.17
286663522017A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination.10
198442552010Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.9

Citation

Dessen P

RFWD3 (ring finger and WD repeat domain 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51515/rfwd3-(ring-finger-and-wd-repeat-domain-3)