ASMT (acetylserotonin O-methyltransferase)

2010-06-01  

Identity

HGNC
LOCATION
Xp22.33
LOCUSID
ALIAS
ASMTY,HIOMT,HIOMTY

Other Information

Locus ID:

NCBI: 438
MIM: 402500
HGNC: 750
Ensembl: ENSG00000196433

Variants:

dbSNP: 438
ClinVar: 438
TCGA: ENSG00000196433
COSMIC: ASMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196433ENST00000381229P46597
ENSG00000196433ENST00000381229X5D2A4
ENSG00000196433ENST00000381233P46597
ENSG00000196433ENST00000381233X5D784
ENSG00000196433ENST00000381241P46597
ENSG00000196433ENST00000381241A0A024RBT9
ENSG00000196433ENST00000432523I7HFW6

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
Melatonin biosynthesis, tryptophan => serotonin => melatoninKEGGhsa_M00037
Melatonin biosynthesis, tryptophan => serotonin => melatoninKEGGM00037
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Amine-derived hormonesREACTOMER-HSA-209776
Serotonin and melatonin biosynthesisREACTOMER-HSA-209931

References

Pubmed IDYearTitleCitations
175054662008Abnormal melatonin synthesis in autism spectrum disorders.105
203778552010Mutation screening of melatonin-related genes in patients with autism spectrum disorders.33
226949572012Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder.27
204427442010Linkage and candidate gene studies of autism spectrum disorders in European populations.24
217784612011Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth.21
204336392010Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder.19
204336392010Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder.19
216154932011Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders.18
227752922013Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway.17
179572332007Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations.15

Citation

Dessen P

ASMT (acetylserotonin O-methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51527/asmt-(acetylserotonin-o-methyltransferase)