ASMT (acetylserotonin O-methyltransferase)

2010-06-01 Affiliation

Identity

HGNC

ASMT

LOCATION

Xp22.33

LOCUSID

438

ALIAS

ASMTY,HIOMT,HIOMTY

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 438
MIM: 402500
HGNC: 750
Ensembl: ENSG00000196433

Variants:

dbSNP: 438
ClinVar: 438
TCGA: ENSG00000196433
COSMIC: ASMT

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196433	ENST00000381229	P46597
ENSG00000196433	ENST00000381229	X5D2A4
ENSG00000196433	ENST00000381233	P46597
ENSG00000196433	ENST00000381233	X5D784
ENSG00000196433	ENST00000381241	P46597
ENSG00000196433	ENST00000381241	A0A024RBT9
ENSG00000196433	ENST00000432523	I7HFW6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Tryptophan metabolism	KEGG	ko00380
Tryptophan metabolism	KEGG	hsa00380
Metabolic pathways	KEGG	hsa01100
Melatonin biosynthesis, tryptophan => serotonin => melatonin	KEGG	hsa_M00037
Melatonin biosynthesis, tryptophan => serotonin => melatonin	KEGG	M00037
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Amine-derived hormones	REACTOME	R-HSA-209776
Serotonin and melatonin biosynthesis	REACTOME	R-HSA-209931

References

Pubmed ID	Year	Title	Citations
33586202	2021	A novel signature predicts recurrence risk and therapeutic response in breast cancer patients.	1
34184492	2021	[Association of polymorphic variants of DDC (AADC), AANAT and ASMT genes encoding enzymes for melatonin synthesis with the higher risk of neuropsychiatric disorders].	0
33586202	2021	A novel signature predicts recurrence risk and therapeutic response in breast cancer patients.	1
34184492	2021	[Association of polymorphic variants of DDC (AADC), AANAT and ASMT genes encoding enzymes for melatonin synthesis with the higher risk of neuropsychiatric disorders].	0
29794137	2018	Restoration of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan-metabolic switch and attenuates cancer progression.	8
29794137	2018	Restoration of hydroxyindole O-methyltransferase levels in human cancer cells induces a tryptophan-metabolic switch and attenuates cancer progression.	8
26510398	2016	Melatonergic system-based two-gene index is prognostic in human gliomas.	0
26510398	2016	Melatonergic system-based two-gene index is prognostic in human gliomas.	0
25059483	2015	Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.	29
26154813	2015	ASMT gene polymorphisms have no association with schizophrenia in a Han Chinese sample.	0
26279084	2015	Bioinformatics Annotation of Human Y Chromosome-Encoded Protein Pathways and Interactions.	5
25059483	2015	Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay.	29
26154813	2015	ASMT gene polymorphisms have no association with schizophrenia in a Han Chinese sample.	0
26279084	2015	Bioinformatics Annotation of Human Y Chromosome-Encoded Protein Pathways and Interactions.	5
23995775	2014	Association between ASMT and autistic-like traits in children from a Swedish nationwide cohort.	8

Citation

Dessen P

ASMT (acetylserotonin O-methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51527/asmt-(acetylserotonin-o-methyltransferase)