Identity
HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
SCAM-1,SCAM1,SH3D4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10174
MIM: 610795
HGNC: 30907
Ensembl: ENSG00000120896
Variants:
dbSNP: 10174
ClinVar: 10174
TCGA: ENSG00000120896
COSMIC: SORBS3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Muscle contraction | REACTOME | R-HSA-397014 |
| Smooth Muscle Contraction | REACTOME | R-HSA-445355 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35822241 | 2023 | Increased SORBS3 expression in brain ageing contributes to autophagic decline via YAP1-WWTR1/TAZ signaling. | 3 |
| 35822241 | 2023 | Increased SORBS3 expression in brain ageing contributes to autophagic decline via YAP1-WWTR1/TAZ signaling. | 3 |
| 34848853 | 2022 | Vinexin contributes to autophagic decline in brain ageing across species. | 4 |
| 34848853 | 2022 | Vinexin contributes to autophagic decline in brain ageing across species. | 4 |
| 28209562 | 2017 | Vinexin β Ablation Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice by Inactivating the Akt-Nuclear Factor κB Inflammatory Axis. | 7 |
| 28209562 | 2017 | Vinexin β Ablation Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice by Inactivating the Akt-Nuclear Factor κB Inflammatory Axis. | 7 |
| 27311882 | 2016 | Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma. | 16 |
| 27437034 | 2016 | Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes. | 11 |
| 27311882 | 2016 | Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma. | 16 |
| 27437034 | 2016 | Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes. | 11 |
| 25824575 | 2015 | Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis. | 2 |
| 25972535 | 2015 | Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation. | 5 |
| 25824575 | 2015 | Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis. | 2 |
| 25972535 | 2015 | Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation. | 5 |
| 20361963 | 2010 | Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo. | 16 |
Citation
Dessen P
SORBS3 (sorbin and SH3 domain containing 3)
Atlas Genet Cytogenet Oncol Haematol. 2010-07-01
Online version: http://atlasgeneticsoncology.org/gene/51545/sorbs3-(sorbin-and-sh3-domain-containing-3)
