IRF9 (interferon regulatory factor 9)

2010-07-01  

Identity

HGNC
LOCATION
14q12
LOCUSID
ALIAS
IRF-9,ISGF3,ISGF3G,p48

Other Information

Locus ID:

NCBI: 10379
MIM: 147574
HGNC: 6131
Ensembl: ENSG00000213928

Variants:

dbSNP: 10379
ClinVar: 10379
TCGA: ENSG00000213928
COSMIC: IRF9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213928ENST00000324076H7BXP4
ENSG00000213928ENST00000396864Q00978
ENSG00000213928ENST00000557894H0YMB0
ENSG00000213928ENST00000559284H0YMB6
ENSG00000213928ENST00000560275H0YNP4
ENSG00000213928ENST00000560852H0YNM9
ENSG00000213928ENST00000561342H0YNM9

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
203890192010NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.84
209436542010Transcription factor redundancy ensures induction of the antiviral state.54
151946802004Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes.51
168493202006Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.50
165951582006Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway.36
125094592003Role of metazoan mediator proteins in interferon-responsive transcription.30
252782622014Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production.30
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
301434812018Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency.27

Citation

Dessen P

IRF9 (interferon regulatory factor 9)

Atlas Genet Cytogenet Oncol Haematol. 2010-07-01

Online version: http://atlasgeneticsoncology.org/gene/51547/irf9-(interferon-regulatory-factor-9)