Identity
HGNC
LOCATION
3q13.2
LOCUSID
ALIAS
LL5b,LL5beta
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 90102
MIM: 610298
HGNC: 29573
Ensembl: ENSG00000144824
Variants:
dbSNP: 90102
ClinVar: 90102
TCGA: ENSG00000144824
COSMIC: PHLDB2
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38397469 | 2024 | Depletion of PHLDB2 Suppresses Epithelial-Mesenchymal Transition and Enhances Anti-Tumor Immunity in Head and Neck Squamous Cell Carcinoma. | 0 |
| 38397469 | 2024 | Depletion of PHLDB2 Suppresses Epithelial-Mesenchymal Transition and Enhances Anti-Tumor Immunity in Head and Neck Squamous Cell Carcinoma. | 0 |
| 37437062 | 2023 | Interfering with the ERC1-LL5β interaction disrupts plasma membrane-Associated platforms and affects tumor cell motility. | 1 |
| 37437062 | 2023 | Interfering with the ERC1-LL5β interaction disrupts plasma membrane-Associated platforms and affects tumor cell motility. | 1 |
| 34952201 | 2022 | PHLDB2 Mediates Cetuximab Resistance via Interacting With EGFR in Latent Metastasis of Colorectal Cancer. | 15 |
| 34952201 | 2022 | PHLDB2 Mediates Cetuximab Resistance via Interacting With EGFR in Latent Metastasis of Colorectal Cancer. | 15 |
| 33320958 | 2021 | Oncometabolite L-2-hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma. | 14 |
| 33452458 | 2021 | NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway. | 15 |
| 34337001 | 2021 | RNA-seq-Based Screening in Coal Dust-Treated Cells Identified PHLDB2 as a Novel Lung Cancer-Related Molecular Marker. | 1 |
| 33320958 | 2021 | Oncometabolite L-2-hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma. | 14 |
| 33452458 | 2021 | NOTCH3, a crucial target of miR-491-5p/miR-875-5p, promotes gastric carcinogenesis by upregulating PHLDB2 expression and activating Akt pathway. | 15 |
| 34337001 | 2021 | RNA-seq-Based Screening in Coal Dust-Treated Cells Identified PHLDB2 as a Novel Lung Cancer-Related Molecular Marker. | 1 |
| 28392396 | 2017 | p53 target miR-29c-3p suppresses colon cancer cell invasion and migration through inhibition of PHLDB2. | 37 |
| 28392396 | 2017 | p53 target miR-29c-3p suppresses colon cancer cell invasion and migration through inhibition of PHLDB2. | 37 |
| 27378169 | 2016 | Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells. | 23 |
Citation
Dessen P
PHLDB2 (pleckstrin homology like domain family B member 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-07-01
Online version: http://atlasgeneticsoncology.org/gene/51562/phldb2-(pleckstrin-homology-like-domain-family-b-member-2)
