BAZ1B (bromodomain adjacent to zinc finger domain 1B)

2010-08-01  

Identity

HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
WBSCR10,WBSCR9,WSTF
FUSION GENES

Other Information

Locus ID:

NCBI: 9031
MIM: 605681
HGNC: 961
Ensembl: ENSG00000009954

Variants:

dbSNP: 9031
ClinVar: 9031
TCGA: ENSG00000009954
COSMIC: BAZ1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000009954ENST00000339594Q9UIG0
ENSG00000009954ENST00000404251Q9UIG0

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
B-WICH complex positively regulates rRNA expressionREACTOMER-HSA-5250924

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
358507722022Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.5
358507722022Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.5
335175642021Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.3
340281252021Williams syndrome transcription factor promotes proliferation and invasion of cervical cancer cells by regulating PI3K/Akt signaling pathway.1
347847072021Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway.2
335175642021Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.3
340281252021Williams syndrome transcription factor promotes proliferation and invasion of cervical cancer cells by regulating PI3K/Akt signaling pathway.1
347847072021Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway.2
320817092020BAZ1B is a candidate gene responsible for hypothyroidism in Williams syndrome.8
322783512020The mutational burden and oligogenic inheritance in Klippel-Feil syndrome.6
325183742020WSTF acetylation by MOF promotes WSTF activities and oncogenic functions.7
320817092020BAZ1B is a candidate gene responsible for hypothyroidism in Williams syndrome.8
322783512020The mutational burden and oligogenic inheritance in Klippel-Feil syndrome.6
325183742020WSTF acetylation by MOF promotes WSTF activities and oncogenic functions.7
302668652019Quantitative Proteomics of the Mitotic Chromosome Scaffold Reveals the Association of BAZ1B with Chromosomal Axes.14

Citation

Dessen P

BAZ1B (bromodomain adjacent to zinc finger domain 1B)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51570/baz1b-(bromodomain-adjacent-to-zinc-finger-domain-1b)