IL18BP (interleukin 18 binding protein)

2010-08-01  

Identity

HGNC
IL18BP
LOCATION
11q13.4
LOCUSID
10068
ALIAS
FVH,IL18BPa

Other Information

Locus ID:

NCBI: 10068
MIM: 604113
HGNC: 5987
Ensembl: ENSG00000137496

Variants:

dbSNP: 10068
ClinVar: 10068
TCGA: ENSG00000137496
COSMIC: IL18BP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137496ENST00000260049O95998
ENSG00000137496ENST00000260049A0A024R5G2
ENSG00000137496ENST00000337131O95998
ENSG00000137496ENST00000337131A0A024R5G2
ENSG00000137496ENST00000343898O95998
ENSG00000137496ENST00000343898A0A024R5I1
ENSG00000137496ENST00000393703O95998
ENSG00000137496ENST00000393703A0A024R5G2
ENSG00000137496ENST00000393705O95998
ENSG00000137496ENST00000393705A0A024R5G2
ENSG00000137496ENST00000393707O95998
ENSG00000137496ENST00000393707A0A024R5M7
ENSG00000137496ENST00000404792O95998
ENSG00000137496ENST00000404792A0A024R5G2
ENSG00000137496ENST00000497194G3V1C5
ENSG00000137496ENST00000531053G3V1C5
ENSG00000137496ENST00000534583O95998
ENSG00000137496ENST00000534583A0A024R5G2
ENSG00000137496ENST00000620017O95998
ENSG00000137496ENST00000620017A0A024R5I1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367422962023Interleukin-18 and IL-18BP in inflammatory dermatological diseases.5
370831542023Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis.0
367422962023Interleukin-18 and IL-18BP in inflammatory dermatological diseases.5
370831542023Interleukin-18 binding protein regulates the apoptosis and necroptosis of fibroblast-like synoviocytes and chondrocytes in rheumatoid arthritis.0
318372152022Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.1
348755842022Interleukin-18 binding protein in infants and children hospitalized with pneumonia in low-resource settings.1
349232222022Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases.14
353980992022Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.11
357058772022Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study.2
318372152022Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.1
348755842022Interleukin-18 binding protein in infants and children hospitalized with pneumonia in low-resource settings.1
349232222022Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases.14
353980992022Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity.11
357058772022Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study.2
345308642021IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis.11

Citation

Dessen P

IL18BP (interleukin 18 binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51571/il18bp-(interleukin-18-binding-protein)