WDR3 (WD repeat domain 3)

2010-08-01 Affiliation

Identity

HGNC

WDR3

LOCATION

1p12

LOCUSID

10885

ALIAS

DIP2,UTP12

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10885
MIM: 604737
HGNC: 12755
Ensembl: ENSG00000065183

Variants:

dbSNP: 10885
ClinVar: 10885
TCGA: ENSG00000065183
COSMIC: WDR3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000065183	ENST00000349139	Q9UNX4
ENSG00000065183	ENST00000349139	Q5TDG3
ENSG00000065183	ENST00000369441	Q6PDA5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ribosome biogenesis in eukaryotes	KEGG	ko03008
Ribosome biogenesis in eukaryotes	KEGG	hsa03008
Gene Expression	REACTOME	R-HSA-74160
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
rRNA modification in the nucleus and cytosol	REACTOME	R-HSA-6790901
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

References

Pubmed ID	Year	Title	Citations
36905106	2023	WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.	1
36905106	2023	WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.	1
33648545	2021	Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer.	7
33648545	2021	Overexpressed WDR3 induces the activation of Hippo pathway by interacting with GATA4 in pancreatic cancer.	7
29309433	2018	Association studies of WD repeat domain 3 and chitobiosyldiphosphodolichol beta-mannosyltransferase genes with schizophrenia in a Japanese population.	0
29309433	2018	Association studies of WD repeat domain 3 and chitobiosyldiphosphodolichol beta-mannosyltransferase genes with schizophrenia in a Japanese population.	0
23049746	2012	Possible role of the WDR3 gene on genome stability in thyroid cancer patients.	2
23049746	2012	Possible role of the WDR3 gene on genome stability in thyroid cancer patients.	2
20392698	2010	Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.	20
20578902	2010	WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population.	7
20578902	2010	WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population.	7
20392698	2010	Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.	20
20578902	2010	WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population.	7
20578902	2010	WDR3 gene haplotype is associated with thyroid cancer risk in a Spanish population.	7

Citation

Dessen P

WDR3 (WD repeat domain 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51576/img/humanGenome