Identity
HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
4EBP2,PHASII
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1979
MIM: 602224
HGNC: 3289
Ensembl: ENSG00000148730
Variants:
dbSNP: 1979
ClinVar: 1979
TCGA: ENSG00000148730
COSMIC: EIF4EBP2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000148730 | ENST00000373218 | Q13542 |
| ENSG00000148730 | ENST00000373218 | A0A024QZM3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| RNA transport | KEGG | ko03013 |
| RNA transport | KEGG | hsa03013 |
| Longevity regulating pathway - multiple species | KEGG | ko04213 |
| Longevity regulating pathway - multiple species | KEGG | hsa04213 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38511550 | 2024 | The human eIF4E:4E-BP2 complex structure for studying hyperphosphorylation. | 0 |
| 38744825 | 2024 | mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. | 0 |
| 38511550 | 2024 | The human eIF4E:4E-BP2 complex structure for studying hyperphosphorylation. | 0 |
| 38744825 | 2024 | mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. | 0 |
| 37797700 | 2023 | 4EBP2-regulated protein translation has a critical role in high-fat diet-induced insulin resistance in hepatocytes. | 0 |
| 37797700 | 2023 | 4EBP2-regulated protein translation has a critical role in high-fat diet-induced insulin resistance in hepatocytes. | 0 |
| 31774674 | 2020 | Multifunnel Energy Landscapes for Phosphorylated Translation Repressor 4E-BP2 and Its Mutants. | 3 |
| 31774674 | 2020 | Multifunnel Energy Landscapes for Phosphorylated Translation Repressor 4E-BP2 and Its Mutants. | 3 |
| 29453322 | 2018 | The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer. | 20 |
| 29453322 | 2018 | The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer. | 20 |
| 28068774 | 2017 | Mechanism of Phosphorylation-Induced Folding of 4E-BP2 Revealed by Molecular Dynamics Simulations. | 5 |
| 28068774 | 2017 | Mechanism of Phosphorylation-Induced Folding of 4E-BP2 Revealed by Molecular Dynamics Simulations. | 5 |
| 26522719 | 2016 | Oncofetal protein IGF2BP3 facilitates the activity of proto-oncogene protein eIF4E through the destabilization of EIF4E-BP2 mRNA. | 34 |
| 26522719 | 2016 | Oncofetal protein IGF2BP3 facilitates the activity of proto-oncogene protein eIF4E through the destabilization of EIF4E-BP2 mRNA. | 34 |
| 25533957 | 2015 | Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. | 256 |
Citation
Dessen P
EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-08-01
Online version: http://atlasgeneticsoncology.org/gene/51579/eif4ebp2-(eukaryotic-translation-initiation-factor-4e-binding-protein-2)
